{"id":16965,"date":"2025-02-16T00:27:33","date_gmt":"2025-02-16T00:27:33","guid":{"rendered":"https:\/\/www.globalresearchdata.kr\/?p=5965"},"modified":"2026-09-13T08:22:48","modified_gmt":"2026-09-12T23:22:48","slug":"homozygous-familial-hypercholesterolemia-market-datam","status":"publish","type":"post","link":"https:\/\/www.globalresearch.co.kr\/insight\/homozygous-familial-hypercholesterolemia-market-datam\/","title":{"rendered":"\uc138\uacc4\uc758 \ub3d9\ud615 \uc811\ud569 \uac00\uc871\uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5 (2024-2031) : \uc57d\ubb3c \ub4f1\uae09\ubcc4 (\uc2a4\ud0c0\ud2f4, \ucf5c\ub808\uc2a4\ud14c\ub864 \ud761\uc218 \uc5b5\uc81c\uc81c, PCSK9 \uc5b5\uc81c\uc81c, MTP \uc5b5\uc81c\uc81c, ANGPTL3 \uc5b5\uc81c\uc81c), \ud22c\uc5ec \uacbd\ub85c (\uacbd\uad6c, \ube44\uacbd\uad6c, \ube44\uac15)"},"content":{"rendered":"

\"\"<\/p>\n

    \n
  1. \ubc29\ubc95\ub860 \ubc0f \ubc94\uc704<\/b>\n
      \n
    1. \uc5f0\uad6c \ubc29\ubc95\ub860<\/li>\n
    2. \ubcf4\uace0\uc11c\uc758 \uc5f0\uad6c \ubaa9\uc801 \ubc0f \ubc94\uc704<\/li>\n<\/ol>\n<\/li>\n
    3. \uc815\uc758 \ubc0f \uac1c\uc694<\/b><\/li>\n
    4. \uc784\uc6d0 \uc694\uc57d<\/b>\n
        \n
      1. \uc57d\ubb3c \uc885\ub958\ubcc4 \uc694\uc57d<\/li>\n
      2. \ud22c\uc5ec \uacbd\ub85c\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n
      3. \uae30\uc220\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n
      4. \uc720\ud1b5 \ucc44\ub110\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n
      5. \uc9c0\uc5ed\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n<\/ol>\n<\/li>\n
      6. \uc5ed\ud559<\/b>\n
          \n
        1. \uc601\ud5a5 \uc694\uc778\n
            \n
          1. \ub3d9\uc778\n
              \n
            1. \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc720\ubcd1\ub960 \uc99d\uac00<\/li>\n
            2. \uc720\uc804\uc790 \uce58\ub8cc\uc758 \uc131\uc7a5\ud558\ub294 \ubc1c\uc804<\/li>\n<\/ol>\n<\/li>\n
            3. \uc81c\uc57d \uc694\uc778\n
                \n
              1. \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uce58\ub8cc\uc640 \uad00\ub828\ub41c \ub192\uc740 \ube44\uc6a9<\/li>\n<\/ol>\n<\/li>\n
              2. \uae30\ud68c\n
                  \n
                1. \uac1c\uc778 \ub9de\ucda4\ud615 \uc758\uc57d\ud488\uc5d0 \ub300\ud55c \uc218\uc694 \uc99d\uac00<\/li>\n<\/ol>\n<\/li>\n
                2. \uc601\ud5a5 \ubd84\uc11d<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n
                3. \uc0b0\uc5c5 \ubd84\uc11d<\/b>\n
                    \n
                  1. \ud3ec\ud130\uc758 5\uac00\uc9c0 \ud798 \ubd84\uc11d<\/li>\n
                  2. \uacf5\uae09\ub9dd \ubd84\uc11d<\/li>\n
                  3. \uac00\uaca9 \ubd84\uc11d<\/li>\n
                  4. \uaddc\uc81c \ubd84\uc11d<\/li>\n<\/ol>\n<\/li>\n
                  5. \ucf54\ub85c\ub09819 \ubd84\uc11d<\/b>\n
                      \n
                    1. \ucf54\ub85c\ub09819 \ubd84\uc11d\n
                        \n
                      1. \ucf54\ub85c\ub09819 \uc774\uc804 \uc2dc\ub098\ub9ac\uc624<\/li>\n
                      2. \ucf54\ub85c\ub09819 \uc911 \uc2dc\ub098\ub9ac\uc624<\/li>\n
                      3. \ucf54\ub85c\ub09819 \uc774\ud6c4 \uc2dc\ub098\ub9ac\uc624<\/li>\n<\/ol>\n<\/li>\n
                      4. \ucf54\ub85c\ub09819\uc5d0 \ub530\ub978 \uac00\uaca9 \uc5ed\ud559<\/li>\n
                      5. \uc218\uc694-\uacf5\uae09 \uc2a4\ud399\ud2b8\ub7fc<\/li>\n
                      6. \ud32c\ub370\ubbf9 \uae30\uac04 \uc911 \uc2dc\uc7a5\uacfc \uad00\ub828\ub41c \uc815\ubd80 \uc774\ub2c8\uc154\ud2f0\ube0c<\/li>\n
                      7. \uc81c\uc870\uc5c5\uccb4\uc758 \uc804\ub7b5\uc801 \uc774\ub2c8\uc154\ud2f0\ube0c<\/li>\n
                      8. \uacb0\ub860<\/li>\n<\/ol>\n<\/li>\n
                      9. \uc57d\ubb3c \ud074\ub798\uc2a4\ubcc4<\/b>\n
                          \n
                        1. \uc18c\uac1c\n
                            \n
                          1. \uc57d\ubb3c \ud074\ub798\uc2a4\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                          2. \uc2dc\uc7a5 \ub9e4\ub825 \uc9c0\uc218, \uc57d\ubb3c \ud074\ub798\uc2a4\ubcc4<\/li>\n<\/ol>\n<\/li>\n
                          3. \uc2a4\ud0c0\ud2f4*\n
                              \n
                            1. \uc18c\uac1c<\/li>\n
                            2. \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<\/ol>\n<\/li>\n
                            3. \ucf5c\ub808\uc2a4\ud14c\ub864 \ud761\uc218 \uc5b5\uc81c\uc81c<\/li>\n
                            4. PCSK9 \uc5b5\uc81c\uc81c<\/li>\n
                            5. MTP \uc5b5\uc81c\uc81c<\/li>\n
                            6. ANGPTL3 \uc5b5\uc81c\uc81c<\/li>\n<\/ol>\n<\/li>\n
                            7. \ud22c\uc5ec \uacbd\ub85c\ubcc4<\/b>\n
                                \n
                              1. \uc18c\uac1c\n
                                  \n
                                1. \ud22c\uc5ec \uacbd\ub85c\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                2. \ud22c\uc5ec \uacbd\ub85c\ubcc4 \uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218<\/li>\n<\/ol>\n<\/li>\n
                                3. \uacbd\uad6c\uc6a9*\n
                                    \n
                                  1. \uc18c\uac1c<\/li>\n
                                  2. \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144\ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<\/ol>\n<\/li>\n
                                  3. \ube44\uacbd\uad6c<\/li>\n
                                  4. \ube44\uac15<\/li>\n<\/ol>\n<\/li>\n
                                  5. \uae30\uc220\ubcc4<\/b>\n
                                      \n
                                    1. \uc18c\uac1c\n
                                        \n
                                      1. \uae30\uc220\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                      2. \uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218, \uae30\uc220\ubcc4<\/li>\n<\/ol>\n<\/li>\n
                                      3. CRISPR-Cas9*\n
                                          \n
                                        1. \uc18c\uac1c<\/li>\n
                                        2. \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<\/ol>\n<\/li>\n
                                        3. RNA \uac04\uc12d<\/li>\n
                                        4. \ub098\ub178\uc785\uc790 \uae30\ubc18 \uce58\ub8cc\ubc95<\/li>\n<\/ol>\n<\/li>\n
                                        5. \uc720\ud1b5 \ucc44\ub110\ubcc4<\/b>\n
                                            \n
                                          1. \uc18c\uac1c\n
                                              \n
                                            1. \uc720\ud1b5 \ucc44\ub110\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144\ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                            2. \uc720\ud1b5 \ucc44\ub110\ubcc4 \uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218<\/li>\n<\/ol>\n<\/li>\n
                                            3. \ubcd1\uc6d0*\n
                                                \n
                                              1. \uc18c\uac1c<\/li>\n
                                              2. \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<\/ol>\n<\/li>\n
                                              3. \uc18c\ub9e4 \uc57d\uad6d<\/li>\n
                                              4. \uc628\ub77c\uc778 \uc57d\uad6d<\/li>\n<\/ol>\n<\/li>\n
                                              5. \uc9c0\uc5ed\ubcc4<\/b>\n
                                                  \n
                                                1. \uc18c\uac1c\n
                                                    \n
                                                  1. \uc9c0\uc5ed\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                                  2. \uc9c0\uc5ed\ubcc4 \uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218<\/li>\n<\/ol>\n<\/li>\n
                                                  3. \ubd81\ubbf8\n
                                                      \n
                                                    1. \uc18c\uac1c<\/li>\n
                                                    2. \uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559\uad00\uacc4<\/li>\n
                                                    3. \uc57d\ubb3c \ud074\ub798\uc2a4 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                    4. \ud22c\uc5ec \uacbd\ub85c \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                    5. \uae30\uc220\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                    6. \uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                    7. \uad6d\uac00 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)\n
                                                        \n
                                                      1. \ubbf8\uad6d<\/li>\n
                                                      2. \uce90\ub098\ub2e4<\/li>\n
                                                      3. \uba55\uc2dc\ucf54<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n
                                                      4. \uc720\ub7fd\n
                                                          \n
                                                        1. \uc18c\uac1c<\/li>\n
                                                        2. \uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n
                                                        3. \uc57d\ubb3c \ud074\ub798\uc2a4\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                                        4. \ud22c\uc5ec \uacbd\ub85c \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                        5. \uae30\uc220\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                        6. \uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                        7. \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%), \uad6d\uac00 \ubcc4\n
                                                            \n
                                                          1. \ub3c5\uc77c<\/li>\n
                                                          2. \uc601\uad6d<\/li>\n
                                                          3. \ud504\ub791\uc2a4<\/li>\n
                                                          4. \uc2a4\ud398\uc778<\/li>\n
                                                          5. \uc774\ud0c8\ub9ac\uc544<\/li>\n
                                                          6. \uae30\ud0c0 \uc720\ub7fd<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n
                                                          7. \ub0a8\ubbf8\n
                                                              \n
                                                            1. \uc18c\uac1c<\/li>\n
                                                            2. \uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n
                                                            3. \uc57d\ubb3c \ud074\ub798\uc2a4\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                                            4. \ud22c\uc5ec \uacbd\ub85c \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                            5. \uae30\uc220\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                            6. \uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                            7. \uad6d\uac00 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)\n
                                                                \n
                                                              1. \ube0c\ub77c\uc9c8<\/li>\n
                                                              2. \uc544\ub974\ud5e8\ud2f0\ub098<\/li>\n
                                                              3. \uae30\ud0c0 \ub0a8\ubbf8<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n
                                                              4. \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591\n
                                                                  \n
                                                                1. \uc18c\uac1c<\/li>\n
                                                                2. \uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n
                                                                3. \uc57d\ubb3c \ud074\ub798\uc2a4\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                                                4. \ud22c\uc5ec \uacbd\ub85c \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                                5. \uae30\uc220\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                                6. \uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                                7. \uad6d\uac00 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)\n
                                                                    \n
                                                                  1. \uc911\uad6d<\/li>\n
                                                                  2. \uc778\ub3c4<\/li>\n
                                                                  3. \uc77c\ubcf8<\/li>\n
                                                                  4. \ud638\uc8fc<\/li>\n
                                                                  5. \uae30\ud0c0 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n
                                                                  6. \uc911\ub3d9 \ubc0f \uc544\ud504\ub9ac\uce74\n
                                                                      \n
                                                                    1. \uc18c\uac1c<\/li>\n
                                                                    2. \uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n
                                                                    3. \uc57d\ubb3c \ud074\ub798\uc2a4\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n
                                                                    4. \ud22c\uc5ec \uacbd\ub85c \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                                    5. \uae30\uc220\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n
                                                                    6. \uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n
                                                                    7. \uacbd\uc7c1 \ud658\uacbd<\/b>\n
                                                                        \n
                                                                      1. \uacbd\uc7c1 \uc2dc\ub098\ub9ac\uc624<\/li>\n
                                                                      2. \uc2dc\uc7a5 \ud3ec\uc9c0\uc154\ub2dd\/\uc810\uc720\uc728 \ubd84\uc11d<\/li>\n
                                                                      3. \uc778\uc218\ud569\ubcd1 \ubd84\uc11d<\/li>\n<\/ol>\n<\/li>\n
                                                                      4. \uae30\uc5c5 \ud504\ub85c\ud544<\/b><\/li>\n<\/ol>\n

                                                                         <\/p>\n

                                                                        \"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

                                                                        \uae00\ub85c\ubc8c \ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5\uc740 2022 \ub144\uc5d0 \ubbf8\ud654 83.7 \ub9cc \ub2ec\ub7ec\uc5d0 \ub3c4\ub2ec\ud588\uc73c\uba70 2023-2030 \ub144 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 2.5 %\uc758 CAGR\ub85c \uc131\uc7a5\ud558\uc5ec 2030 \ub144\uae4c\uc9c0 \ubbf8\ud654 1 \uc5b5 1,180 \ub9cc \ub2ec\ub7ec\uc5d0\uc774\ub97c\uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.
                                                                        \nHoFH\ub97c \uc720\ubc1c\ud558\ub294 \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc815\ud655\ud558\uac8c \uc2dd\ubcc4\ud558\uc5ec \uc870\uae30 \uc9c4\ub2e8\uc744 \uc6a9\uc774\ud558\uac8c\ud558\ub294 \uc720\uc804\uc790 \uc9c4\ub2e8\uc758 \ubc1c\uc804\uc73c\ub85c\uc758 \uc804\ud658\uacfc \uac19\uc740 \ucd94\uc138\ub294 \uae00\ub85c\ubc8c \ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5\uc744 \uc9c0\ubc30 \ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.
                                                                        \n\uae00\ub85c\ubc8c \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uc2dc\uc7a5\uc740 \ucd5c\uadfc \uba87 \ub144 \ub3d9\uc548 \ud06c\uac8c \uc131\uc7a5\ud588\uc73c\uba70 \uc55e\uc73c\ub85c\ub3c4 \uc0c1\uc2b9 \ucd94\uc138\ub97c \uc774\uc5b4\uac08 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \uc774 \uc2dc\uc7a5\uc740 CRISPR-Cas9 \ubc0f RNA \uac04\uc12d(RNAi)\uacfc \uac19\uc740 \uc0c8\ub85c\uc6b4 \uae30\uc220\uc758 \uac1c\ubc1c\uacfc \uac19\uc740 \uba87 \uac00\uc9c0 \uc911\uc694\ud55c \ucd94\uc138\uc758 \uc601\ud5a5\uc744 \ubc1b\uc544 \ubcc0\ud601\uae30\ub97c \uacaa\uace0 \uc788\uc2b5\ub2c8\ub2e4.
                                                                        \n\ub610\ud55c \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc720\ubcd1\ub960 \uc99d\uac00, \ub2e8\uc77c \ud074\ub860 \ud56d\uccb4\uc640 \uac19\uc740 \uc7a0\uc7ac\uc801 \uc778 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc758 \ucd9c\uc2dc, \uc9c8\ubcd1\uc5d0 \ub300\ud55c \uc778\uc2dd \uc99d\uac00, \uc784\uc0c1 \uc2dc\ud5d8\uc758 \uc99d\uac00\ub294 \ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5 \uaddc\ubaa8\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 \uc788\uc2b5\ub2c8\ub2e4.
                                                                        \n\ub3d9\ud615 \uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uc811\uadfc \ubc29\uc2dd\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud558\uae30\uc704\ud55c \uc5f0\uad6c \ud65c\ub3d9\uc774 \uc99d\uac00\ud558\uace0 \ubc14\uc774\uc624 \uc81c\uc57d \ubc0f \uc81c\uc57d \ud68c\uc0ac\uac00 \uc124\ub9bd\ub418\ub294 \uac83\uc740 \ubd81\ubbf8 \uc9c0\uc5ed\uc758 \uc218\uc694 \uc694\uc778 \uc911 \uc77c\ubd80\uc785\ub2c8\ub2e4. \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74, \ube44\uc544\ud2b8\ub9ac\uc2a4, \uc5b4\ucf54\ub4dc \ud5ec\uc2a4\ucf00\uc5b4 \ub4f1 \uc8fc\uc694 \uacbd\uc7c1\uc5c5\uccb4\ub4e4\uc774 \uc2dc\uc7a5\uc5d0\uc11c \ud65c\ubc1c\ud788 \ud65c\ub3d9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

                                                                        \uc2dc\uc7a5 \uc5ed\ud559
                                                                        \n\ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5\uc758 \uc131\uc7a5\uc744 \uc8fc\ub3c4\ud558\ub294 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc720\ubcd1\ub960 \uc99d\uac00
                                                                        \n\uc2ec\ud608\uad00 \uc9c8\ud658(CVD)\uc758 \uc720\ubcd1\ub960 \uc99d\uac00\ub294 \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d(HoFH) \uc2dc\uc7a5\uc758 \uc8fc\uc694 \ub3d9\uc778\uc785\ub2c8\ub2e4. HoFH\ub294 \ub192\uc740 LDL-C \uc218\uce58\uc640 \uc2ec\uc7a5\ub9c8\ube44 \ubc0f \ub1cc\uc878\uc911\uacfc \uac19\uc740 CVD \uc704\ud5d8 \uc99d\uac00\ub97c \ud2b9\uc9d5\uc73c\ub85c \ud558\ubbc0\ub85c, \uc774 \uc9c8\ud658\uc5d0 \ub300\ud55c \uc778\uc2dd\uc774 \ub192\uc544\uc9c0\uba74\uc11c \uc870\uae30 \ubc1c\uacac \ubc0f \uac1c\uc785\uc774 \ucd09\uc9c4\ub418\uace0 \ud6a8\uc728\uc801\uc778 HoFH \uce58\ub8cc\ubc95\uc5d0 \ub300\ud55c \uc218\uc694\uac00 \uc99d\uac00\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.
                                                                        \n\uc608\ub97c \ub4e4\uc5b4, \ubbf8\uad6d \uc9c8\ubcd1\ud1b5\uc81c\uc608\ubc29\uc13c\ud130 2023 \ubcf4\uace0\uc11c\uc5d0 \ub530\ub974\uba74 \uc2ec\uc7a5\ubcd1\uc740 \ubbf8\uad6d \ub0b4 \uc8fc\uc694 \uc0ac\ub9dd \uc6d0\uc778 \uc911 \ud558\ub098\ub85c, 40\ucd08\ub9c8\ub2e4 \ud55c \uba85 \ub610\ub294 \ub2e4\ub978 \uc0ac\ub78c\uc774 \uc2ec\uc7a5\ub9c8\ube44\ub85c \uc0ac\ub9dd\ud569\ub2c8\ub2e4. \ubbf8\uad6d\uc5d0\uc11c\ub294 \ub9e4\ub144 \uc57d 805,000\uba85\uc758 \uc0ac\ub78c\ub4e4\uc774 \uc2ec\uc7a5\ub9c8\ube44\ub97c \uacaa\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uad00\uc0c1\ub3d9\ub9e5 \uc2ec\uc7a5 \uc9c8\ud658\uc740 \uac00\uc7a5 \ud754\ud55c \uc720\ud615\uc758 \uc2ec\uc7a5 \uc9c8\ud658\uc73c\ub85c, 2021\ub144\uc5d0 375,476\uba85\uc774 \uc0ac\ub9dd\ud588\uc2b5\ub2c8\ub2e4. CVD \ubc0f \uad00\uc0c1\ub3d9\ub9e5 \uc2ec\uc7a5 \uc9c8\ud658\uc758 \ubd80\ub2f4\uc774 \uacc4\uc18d \uc99d\uac00\ud568\uc5d0 \ub530\ub77c HoFH \uc2dc\uc7a5\uc740 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.
                                                                        \n\uc720\uc804\uc790 \uce58\ub8cc\uc758 \ubc1c\uc804\uc73c\ub85c \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uc2dc\uc7a5 \uc131\uc7a5 \uacac\uc778\ud560 \uac83
                                                                        \nCRISPR-Cas9, \uc791\uc740 \uac04\uc12d RNA (SiRNA), \uc5d1\uc18c\uc880 \ub9e4\uac1c \uce58\ub8cc \ub4f1\uacfc \uac19\uc740 \ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d\uc758 \uae30\uc220 \ubc1c\uc804\uc774 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \uc2dc\uc7a5\uc5d0 \ub300\ud55c \uc218\uc694\uac00 \uc99d\uac00 \ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. CRISPR\/Cas9 \uc2dc\uc2a4\ud15c\uc740 ZFN\uacfc TALEN\uc5d0 \uc774\uc740 \ud601\uc2e0\uc801\uc778 3\uc138\ub300 \uc720\uc804\uc790 \ud3b8\uc9d1 \ub3c4\uad6c\ub85c, \ud604\uc7ac \uac00\uc7a5 \ub9ce\uc774 \uc0ac\uc6a9\ub418\ub294 \uc720\uc804\uccb4 \ud3b8\uc9d1 \ub3c4\uad6c\uc785\ub2c8\ub2e4.
                                                                        \n\uc608\ub97c \ub4e4\uc5b4, \ubbf8\uad6d\uad6d\ub9bd\uc758\ud559\ub3c4\uc11c\uad00 2022 \ub17c\ubb38\uc5d0 \ub530\ub974\uba74, \ucd5c\uadfc \uc0dd\uccb4 \ub0b4 \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c LDL \uc218\uc6a9\uccb4 \uae30\ub2a5\uc774 \uc190\uc0c1\ub41c LDLR \ub3cc\uc5f0\ubcc0\uc774 \ub9c8\uc6b0\uc2a4\ub97c \ud45c\uc801\uc73c\ub85c \uc0bc\uae30 \uc704\ud574 CRISPR\/Cas9 \uc720\uc804\uc790 \ud3b8\uc9d1 \uc2dc\uc2a4\ud15c(AAV-CRISPR\/Cas9)\uc774 \ud3ec\ud568\ub41c \uc544\ub370\ub178 \uad00\ub828 \ubc14\uc774\ub7ec\uc2a4(AAV)\ub97c \uc0ac\uc6a9\ud588\ub2e4\uace0 \ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 AAV-CRISPR\/Cas9 \uc720\uc804\uc790 \ud3b8\uc9d1\uc744 \uc0ac\uc6a9\ud558\uc5ec \uac04\uc138\ud3ec\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub97c \ubd80\ubd84\uc801\uc73c\ub85c \uc218\uc815\ud558\uc5ec LDL \uc218\uc6a9\uccb4 \ub2e8\ubc31\uc9c8 \ubc1c\ud604\uc744 \ud68c\ubcf5\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.
                                                                        \n\uadf8 \uacb0\uacfc \ud608\uccad \ucd1d \ucf5c\ub808\uc2a4\ud14c\ub864, \uc911\uc131\uc9c0\ubc29, LDL \ucf5c\ub808\uc2a4\ud14c\ub864 \uc218\uce58\uac00 \ud06c\uac8c \uac10\uc18c\ud588\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc \ub300\ub3d9\ub9e5\uc758 \uc8fd\uc0c1 \uacbd\ud654\uc131 \ud50c\ub77c\ud06c \ud615\uc131\uc774 \ud06c\uac8c \uac10\uc18c\ud558\uc5ec \uc774\ud615\uc811\ud569 \ubc0f \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uce58\ub8cc\uc5d0 \ub300\ud55c CRISPR\/Cas9\uc758 \uc7a0\uc7ac\uc801 \uac00\ub2a5\uc131\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc720\uc804\uc790 \uce58\ub8cc \uae30\uc220\uc758 \ubc1c\uc804\uc740 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uc2dc\uc7a5\uc5d0 \ub300\ud55c \uc218\uc694\ub97c \uc8fc\ub3c4 \ud560 \uac83\uc785\ub2c8\ub2e4.
                                                                        \n\ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uce58\ub8cc\uc640 \uad00\ub828\ub41c \ub192\uc740 \ube44\uc6a9\uc740 \uc2dc\uc7a5\uc758 \uc131\uc7a5\uc744 \ubc29\ud574 \ud560 \uac83\uc785\ub2c8\ub2e4.
                                                                        \n\ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d\uc5d0 \ub300\ud55c \ub192\uc740 \uce58\ub8cc \ube44\uc6a9\uc740\uc774 \uc2dc\uc7a5\uc758 \uc911\uc694\ud55c \uc7a5\ubcbd\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc57d\ubb3c\uc758 \ub192\uc740 \ube44\uc6a9\uc73c\ub85c \uc778\ud574 \ud658\uc790\ub4e4\uc774 \uac10\ub2f9\ud558\uae30 \uc5b4\ub824\uc6cc \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774 \uc774\ub7ec\ud55c \uc911\uc694\ud55c \uce58\ub8cc\ubc95\uc744 \uc5bb\uc9c0 \ubabb\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc7ac\uc815\uc801 \ubd80\ub2f4\uc740 \uc800\uc18c\ub4dd \uc9c0\uc5ed\uc758 \ub354 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc73c\uba70, \uc774\ub85c \uc778\ud574 HoFH \ud658\uc790\uc758 \uc0dd\uba85\uc744 \uad6c\ud560 \uc218 \uc788\ub294 \uce58\ub8cc\uc81c\ub97c \ubc1b\uc744 \uc218 \uc788\ub294 \uc0ac\ub78c\ub4e4\uacfc\uc758 \uaca9\ucc28\uac00 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.
                                                                        \n\uc608\ub97c \ub4e4\uc5b4, \ubbf8\uad6d\uc5d0\uc11c \uc800\ubc00\ub3c4 \uc9c0\ub2e8\ubc31(LDL) \ucf5c\ub808\uc2a4\ud14c\ub864 \uc218\uce58\ub97c \ub0ae\ucd94\ub294 \ub370 \uc0ac\uc6a9\ub418\ub294 \ub85c\ubbf8\ud0c0\ud53c\ub4dc(Lomitapide)\ub77c\ub294 \uc57d\ud488\uc740 \uc57d 1\ub9cc \ub2ec\ub7ec\uc5d0 \ud310\ub9e4\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uacbd\uad6c\uc6a9 5mg \ucea1\uc290\uc740 28\ucea1\uc290 \uacf5\uae09\uc5d0 \uc57d 53,471\ub2ec\ub7ec\uc785\ub2c8\ub2e4. \uac8c\ub2e4\uac00 \uc81c\ub124\ub9ad \ubc84\uc804\uc774 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \uac1c\ubc1c\ub3c4\uc0c1\uad6d \ubc0f \uc800\uc18c\ub4dd \uad6d\uac00\uc5d0\uc11c\ub294 \ud30c\ud14c\ud2f4\uc744 \uad6c\uc785\ud558\uae30 \uc5b4\ub824\uc6b8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc704\uc758 \uc694\uc778\uc73c\ub85c \uc778\ud574 \uc2dc\uc7a5\uc740 \uac00\uae4c\uc6b4 \uc7a5\ub798\uc5d0 \uc81c\uc57d\uc5d0 \uc9c1\uba74 \ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.
                                                                        \n\uc138\uadf8\uba3c\ud2b8 \ubd84\uc11d
                                                                        \n\uae00\ub85c\ubc8c \ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5\uc740 \uc57d\ubb3c \ub4f1\uae09, \ud22c\uc5ec \uacbd\ub85c, \uae30\uc220, \uc720\ud1b5 \ucc44\ub110 \ubc0f \uc9c0\uc5ed\uc5d0 \ub530\ub77c \uc138\ubd84\ud654\ub429\ub2c8\ub2e4.
                                                                        \n\ub354 \ub098\uc740 \ud6a8\uacfc\ub85c \uc778\ud574 \uc2a4\ud0c0\ud2f4 \ubd80\ubb38\uc740 \ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 \uc57d 47.6 %\ub97c \ucc28\uc9c0\ud588\uc2b5\ub2c8\ub2e4.
                                                                        \n\uc2a4\ud0c0\ud2f4 \ubd80\ubb38\uc740 LDL \ucf5c\ub808\uc2a4\ud14c\ub864 \uc218\uce58\ub97c \ub0ae\ucd94\uace0 \uc2ec\ud608\uad00 \uc704\ud5d8\uc744 \uad00\ub9ac\ud558\ub294 \ub370 \ud6a8\uacfc\uc801\uc774\uae30 \ub54c\ubb38\uc5d0 \ub3d9\ud615 \uc811\ud569 \uac00\uc871\uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5\uc744 \uc9c0\ubc30 \ud560 \uc900\ube44\uac00\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc2a4\ud0c0\ud2f4\uc740 3-\ud558\uc774\ub4dc\ub85d\uc2dc-3-\uba54\ud2f8\uae00\ub8e8\ud0c0\ub9b4 \ucf54\uc5d4\uc790\uc784-A(HMG-CoA)-\ud658\uc6d0\ud6a8\uc18c\uc5d0 \uc791\uc6a9\ud558\uc5ec \uac04 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud569\uc131\uc744 \uac10\uc18c\uc2dc\ucf1c LDL-C\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \ub2a5\ub825\uc73c\ub85c \uc778\ud574 \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uce58\ub8cc\uc758 \uc8fc\uc694 \uce58\ub8cc\uc81c\ub85c \uc0ac\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.
                                                                        \n\ub610\ud55c \uc8fd\uc0c1\ub3d9\ub9e5\uacbd\ud654\uc99d\uc758 \uc720\ubcd1\ub960\uc774 \uc99d\uac00\ud558\ub294 \uac83\ub3c4 \uc2a4\ud0c0\ud2f4\uacfc \uac19\uc740 \uce58\ub8cc\uc81c\uac00 \ub9e4\uc6b0 \ud6a8\uacfc\uc801\uc778 \uc8fc\uc694 \uc694\uc778\uc785\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uac00\uc871 \uc2ec\uc7a5 \uc7ac\ub2e8 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc2a4\ud0c0\ud2f4\uc740 LDL \ucf5c\ub808\uc2a4\ud14c\ub864\uc744 35~55%\uae4c\uc9c0 \ub0ae\ucd9c \uc218 \uc788\uc73c\uba70 LDL \ucf5c\ub808\uc2a4\ud14c\ub864\uc774 40mg\/dL \uac10\uc18c\ud560 \ub54c\ub9c8\ub2e4 \uc2ec\ud608\uad00 \uc9c8\ud658\uc758 \uc704\ud5d8\uc744 22%\uae4c\uc9c0 \uc904\uc77c \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.
                                                                        \n\ud604\uc7ac \ub85c\uc218\ubc14\uc2a4\ud0c0\ud2f4\uc740 \ud604\uc7ac \uc0ac\uc6a9 \uac00\ub2a5\ud55c \uc2a4\ud0c0\ud2f4 \uc911 \uac00\uc7a5 \uac15\ub825\ud55c \uc9c0\uc9c8 \uac15\ud558 \uae30\ub2a5\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \uc6d0\ubc1c\uc131 \uace0\uc9c0\ud608\uc99d\uacfc \ud63c\ud569\ud615 \uc774\uc0c1\uc9c0\uc9c8\ud608\uc99d, \ub3d9\ud615\uc811\ud569 FH, \uc6d0\ubc1c\uc131 \uc774\uc0c1\uc9c0\uc9c8\ud608\uc99d \ubc0f \uace0\uc911\uc131\uc9c0\ubc29\ud608\uc99d \ud658\uc790\uc5d0\uac8c \uad8c\uc7a5\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc2a4\ud0c0\ud2f4\uc740 \uc5b4\ub9b0\uc774\uc5d0\uac8c \ub9e4\uc6b0 \ud6a8\uacfc\uc801\uc774\uba70 \uc9c0\uc9c8 \uc7a5\uc560\ub97c \uc553\uace0 \uc788\ub294 \uc5b4\ub9b0\uc774\uc5d0\uac8c\ub3c4 \uc548\uc804\ud55c \uac83\uc73c\ub85c \uc785\uc99d\ub418\uc5c8\uc2b5\ub2c8\ub2e4.
                                                                        \n\ub610\ud55c \uc2a4\ud0c0\ud2f4\uc740 \uc5d0\ube44\ub098\ucfe0\ub9d9, PCSK9 \uc5b5\uc81c\uc81c \ub4f1\uacfc \uac19\uc740 \ub2e4\ub978 \ubcf4\uc870 \uce58\ub8cc\uc81c\uc640 \ud568\uaed8 \ud22c\uc5ec\ud560 \ub54c \ub354\uc6b1 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4. \uc2a4\ud0c0\ud2f4\uc758 \ubcf4\uc870\uc81c\ub85c \uc0ac\uc6a9\ub418\ub294 \ub9ce\uc740 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc774 FDA \uc2b9\uc778\uc744 \ubc1b\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc2a4\ud0c0\ud2f4\uc758 \ub354 \ub098\uc740 \ud6a8\uacfc\ub85c \uc778\ud574\uc774 \uc138\uadf8\uba3c\ud2b8\ub294 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uc9c0\ubc30\uc801 \uc77c \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.
                                                                        \n\uc9c0\ub9ac\uc801 \uc810\uc720\uc728
                                                                        \n\ubd81\ubbf8\ub294 \uc8fd\uc0c1 \uacbd\ud654\uc131 \uc2ec\ud608\uad00 \uc9c8\ud658 (ASCVD)\uc758 \uc720\ubcd1\ub960 \uc99d\uac00\ub85c \uc778\ud574 2022 \ub144 \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 \uc57d 41.7 %\ub97c \ucc28\uc9c0\ud588\uc2b5\ub2c8\ub2e4.
                                                                        \n\ubd81\ubbf8, \ud2b9\ud788 \ubbf8\uad6d\uc740\uc774 \uc9c0\uc5ed\uc5d0 \uc815\ucc29 \ud55c \uc218\ub9ce\uc740 \uc8fc\uc694 \uc5c5\uccb4\uc758 \uc874\uc7ac, \uc8fd\uc0c1 \uacbd\ud654\uc131 \uc2ec\ud608\uad00 \uc9c8\ud658 (ASCVD)\uc758 \uc720\ubcd1\ub960 \uc99d\uac00, \uc9c0\uc5ed \ub0b4 \uc8fc\uc694 \uae30\uad00\uc758 \uae30\uc220 \uac1c\ubc1c\uacfc \ud568\uaed8 \ub192\uc740 \uc5f0\uad6c \ud65c\ub3d9\uc73c\ub85c \uc778\ud574 \uae00\ub85c\ubc8c \ub3d9\ud615 \uc811\ud569 \uac00\uc871 \uc131 \uace0 \ucf5c\ub808\uc2a4\ud14c\ub864 \ud608\uc99d \uc2dc\uc7a5\uc744 \uc9c0\ubc30\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.
                                                                        \n\uc608\ub97c \ub4e4\uc5b4, \ubbf8\uad6d \uad6d\ub9bd\uc758\ud559\ub3c4\uc11c\uad00 2022 \ub17c\ubb38\uc5d0 \ub530\ub974\uba74 2019\ub144 \ubbf8\uad6d \ub0b4 ASCVD \uc720\ubcd1\ub960\uc740 \uc57d 2,400\ub9cc \uba85\uc73c\ub85c, \ubbf8\uad6d \uc804\uccb4 \uc778\uad6c\uc758 \uc57d 10%\uac00 21\uc138 \uc774\uc0c1\uc785\ub2c8\ub2e4. ASCVD \ud658\uc790\uc758 \ub3d9\ubc18 \uc9c8\ud658 \ubd80\ub2f4\uc774 \ud06c\uace0 31.2%\ub294 \uc7ac\ubc1c \uc704\ud5d8\uc774 \ub9e4\uc6b0 \ub192\uc740 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc704\uc758 \uc694\uc778\uc73c\ub85c \uc778\ud574\uc774 \uc9c0\uc5ed\uc740 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<\/p>\n

                                                                        \ucf54\ub85c\ub09819 \uc601\ud5a5 \ubd84\uc11d
                                                                        \n\ucf54\ub85c\ub09819 \ud32c\ub370\ubbf9\uc740 \ud2b9\ud788 \ub3d9\ud615\uc811\ud569 \ud608\uc6b0\ubcd1(HoFH) \ud658\uc790\uc758 \ub77c\uc774\ud504\uc2a4\ud0c0\uc77c\uacfc \uad00\ub9ac\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\ucce4\uc2b5\ub2c8\ub2e4. \ucf54\ub85c\ub09819\uc5d0 \ub300\ud55c \ub450\ub824\uc6c0\uc73c\ub85c \uc778\ud574 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774 \uce58\ub8cc\ub97c \ubc1b\ub294 \uac83\uc744 \uae30\ud53c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac8c\ub2e4\uac00 FH \ud658\uc790\ub294 \ucf54\ub85c\ub09819 \uac10\uc5fc\uc5d0 \ub354 \ucde8\uc57d\ud558\ub2e4\ub294 \uc774\uc720\ub85c \uace0\uc704\ud5d8\uad70\uc73c\ub85c \uc9c0\uc815\ub418\uc5b4 \ud32c\ub370\ubbf9 \uae30\uac04 \ub3d9\uc548 \uc2ec\ud608\uad00 \uce58\ub8cc \ubc0f \uc608\ubc29\uc5d0 \ub300\ud55c FH \ud658\uc790\uc758 \uc811\uadfc\uc131\uc774 \uc81c\ud55c\ub418\uc5c8\uc2b5\ub2c8\ub2e4.
                                                                        \n\ucc38\uace0\ub85c 2022\ub144 \uad6d\ub9bd\uc758\ud559\ub3c4\uc11c\uad00 \ub17c\ubb38\uc5d0 \ub530\ub974\uba74, \uc774 \uc778\uad6c \uae30\ubc18 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ucf54\ub85c\ub09819\uc5d0 \uac78\ub9b0 FH \ud658\uc790\ub294 \uae09\uc131 \uc2ec\uadfc\uacbd\uc0c9 \uc704\ud5d8\uc774 \uc0c1\ub2f9\ud788 \ub192\uc740 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc804\ubc18\uc801\uc73c\ub85c \ucf54\ub85c\ub09819 \ud32c\ub370\ubbf9\uc73c\ub85c \uc778\ud574 FH \ud658\uc790, \ud2b9\ud788 HoFH \ud658\uc790\uc758 \uc2ec\ud608\uad00 \uce58\ub8cc\uc5d0 \uc7a5\uc560\ubb3c\uc774 \uc0dd\uacbc\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uc2dc\uc7a5\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc788\uc2b5\ub2c8\ub2e4.
                                                                        \n\uc57d\ubb3c \uc885\ub958\ubcc4
                                                                        \n\uc2a4\ud0c0\ud2f4
                                                                        \n\ucf5c\ub808\uc2a4\ud14c\ub864 \ud761\uc218 \uc5b5\uc81c\uc81c
                                                                        \nPCSK9 \uc5b5\uc81c\uc81c
                                                                        \nMTP \uc5b5\uc81c\uc81c
                                                                        \nANGPTL3 \uc5b5\uc81c\uc81c
                                                                        \n\ud22c\uc5ec \uacbd\ub85c\ubcc4
                                                                        \n\uacbd\uad6c
                                                                        \n\ube44\uacbd\uad6c
                                                                        \n\ube44\uac15
                                                                        \n\uae30\uc220\ubcc4
                                                                        \nCRISPR-Cas9
                                                                        \nRNA \uac04\uc12d
                                                                        \n\ub098\ub178\uc785\uc790 \uae30\ubc18 \uce58\ub8cc\ubc95
                                                                        \n\uc720\ud1b5 \ucc44\ub110\ubcc4
                                                                        \n\ubcd1\uc6d0
                                                                        \n\uc18c\ub9e4 \uc57d\uad6d
                                                                        \n\uc628\ub77c\uc778 \uc57d\uad6d
                                                                        \n\uc9c0\uc5ed\ubcc4
                                                                        \n\ubd81\ubbf8
                                                                        \n\ubbf8\uad6d
                                                                        \n\uce90\ub098\ub2e4
                                                                        \n\uba55\uc2dc\ucf54
                                                                        \n\uc720\ub7fd
                                                                        \n\ub3c5\uc77c
                                                                        \n\uc601\uad6d
                                                                        \n\ud504\ub791\uc2a4
                                                                        \n\uc2a4\ud398\uc778
                                                                        \n\uc774\ud0c8\ub9ac\uc544
                                                                        \n\uae30\ud0c0 \uc720\ub7fd
                                                                        \n\ub0a8\ubbf8
                                                                        \n\ube0c\ub77c\uc9c8
                                                                        \n\uc544\ub974\ud5e8\ud2f0\ub098
                                                                        \n\uae30\ud0c0 \ub0a8\ubbf8
                                                                        \n\uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591
                                                                        \n\uc911\uad6d
                                                                        \n\uc778\ub3c4
                                                                        \n\uc77c\ubcf8
                                                                        \n\ud638\uc8fc
                                                                        \n\uae30\ud0c0 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed
                                                                        \n\uc911\ub3d9 \ubc0f \uc544\ud504\ub9ac\uce74
                                                                        \n\uc8fc\uc694 \uac1c\ubc1c \ud604\ud669
                                                                        \n2023\ub144 3\uc6d4 22\uc77c, \ub9ac\uc81c\ub124\ub860 \ud30c\ub9c8\uc288\ud2f0\uceec\uc2a4\ub294 FDA\uac00 \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d(HoFH)\uc774 \uc788\ub294 5~11\uc138 \uc18c\uc544\uc5d0\uc11c \ub2e4\ub978 \uc9c0\uc9c8 \uc800\ud558 \uc758\uc57d\ud488\uc5d0 \ucd94\uac00\ud558\uc5ec Evkeeza(\uc5d0\ube44\ub098\ucfe0\ub9d9-dgnb)\uc758 \uc2b9\uc778\uc744 \uc5f0\uc7a5\ud588\ub2e4\uace0 \ubc1c\ud45c\ud588\uc2b5\ub2c8\ub2e4. \uc5d0\ube0c\ud0a4\uc790\ub294 5\uc138 \uc774\ud558\uc758 \uc5b4\ub9b0\uc774\uc5d0\uac8c HoFH\ub85c \uc778\ud55c \uc704\ud5d8\ud560 \uc815\ub3c4\ub85c \ub192\uc740 \uc800\ubc00\ub3c4 \uc9c0\ub2e8\ubc31 \ucf5c\ub808\uc2a4\ud14c\ub864(LDL-C) \uc218\uce58\ub97c \ub0ae\ucd94\uae30 \uc704\ud574 \uc2b9\uc778\ub41c \ucd5c\ucd08\uc758 \uc548\uc9c0\uc624\ud3ec\uc774\uc5d0\ud2f4 \uc720\uc0ac 3(ANGPTL3) \uc5b5\uc81c\uc81c \uc57d\ubb3c\uc785\ub2c8\ub2e4.
                                                                        \n2021\ub144 4\uc6d4 1\uc77c, FDA\ub294 \ucf5c\ub808\uc2a4\ud14c\ub864 \uc218\uce58\uac00 \ud604\uc800\ud788 \ub192\uc544\uc9c0\ub294 \uc720\uc804\uc131 \uc9c8\ud658\uc778 \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d(HoFH) \uc131\uc778 \ud658\uc790\ub97c \uc704\ud55c \uc8fc\uc0ac\uc81c Praluent(\uc54c\ub9ac\ub85c\ucfe0\ub9d9)\ub97c \uc2b9\uc778\ud588\uc2b5\ub2c8\ub2e4. \ud504\ub784\ub7f0\ud2b8\ub294 \ub2e8\ub3c5\uc73c\ub85c \ubcf5\uc6a9\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c \ub2e4\ub978 HoFH \uce58\ub8cc\uc81c\uc640 \ubcd1\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4.
                                                                        \nDMI \uc758\uacac
                                                                        \n\uae00\ub85c\ubc8c \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d(HoFH) \uc2dc\uc7a5\uc740 \uc720\uc804\uc790 \uc9c4\ub2e8\uc758 \ubc1c\uc804, CRISPR-Cas9\uacfc \uac19\uc740 \uc720\uc804\uc790 \uce58\ub8cc\ubc95, \uc9c8\ud658\uc5d0 \ub300\ud55c \uc778\uc2dd \uc99d\uac00\ub85c \uc778\ud574 \uae09\uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. HoFH\uc640 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc0ac\uc774\uc758 \uc5f0\uad00\uc131\uc740 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc\ubc95\uc5d0 \ub300\ud55c \uc218\uc694\ub97c \ucc3d\ucd9c\ud558\uc9c0\ub9cc, \uce58\ub8cc\uc758 \uacbd\uc81c\uc131\uacfc \uc811\uadfc\uc131 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\ub294 \uac83\uc774 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. \uc720\uc804\uc790 \ud3b8\uc9d1 \uae30\uc220\uc740 \uc5c4\uccad\ub09c \uac00\ub2a5\uc131\uc744 \uac00\uc9c0\uace0 \uc788\uc9c0\ub9cc \ubb38\uc81c\uc640 \uc548\uc804\uc131 \ubb38\uc81c\uac00 \uc5c6\ub294 \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4.
                                                                        \n\uc2dc\uc7a5\uc740 \uba87 \uac00\uc9c0 \ud2b9\uc131\uc5d0 \ub530\ub77c \uc138\ubd84\ud654\ub418\uc5b4 \uc788\uc73c\uba70, \uc5f0\uad6c \uc5ed\ub7c9\uacfc \uc9c8\ubcd1 \ubc1c\uc0dd\ub960\ub85c \uc778\ud574 \ubd81\ubbf8\uac00 \uc9c0\ubc30\uc801\uc778 \uc2dc\uc7a5\uc785\ub2c8\ub2e4. \ucf54\ub85c\ub09819\ub294 \uac15\ub825\ud55c \uc758\ub8cc \uc2dc\uc2a4\ud15c\uacfc \uce58\ub8cc\uc5d0 \ub300\ud55c \ub3d9\ub4f1\ud55c \uc811\uadfc\uc131\uc758 \uc911\uc694\uc131\uc744 \uac15\uc870\ud558\ub294 \ubc18\uba74, \uc5d0\ube0c\ud0a4\uc790 \ubc0f \ud504\ub784\ub8e8\uc5d4\ud2b8\uc640 \uac19\uc740 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc740 \uc9c0\uc18d\uc801\uc778 \ud601\uc2e0\uc744 \ubcf4\uc5ec\uc8fc\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud658\uacbd\uc744 \ud5e4\uccd0\ub098\uac00\ub294 \ub370 \uc788\uc5b4 \uac1c\ubc1c\uacfc \uc724\ub9ac\uc801 \ubb38\uc81c\uc758 \uade0\ud615\uc744 \ub9de\ucd94\ub294 \uac83\uc740 \uc5ec\uc804\ud788 \uc911\uc694\ud55c \uacfc\uc81c\uc785\ub2c8\ub2e4.
                                                                        \n\ubcf4\uace0\uc11c\ub97c \uad6c\ub9e4\ud558\ub294 \uc774\uc720\ub294 \ubb34\uc5c7\uc778\uac00\uc694?
                                                                        \n\uc57d\ubb3c \ud074\ub798\uc2a4, \ud22c\uc5ec \uacbd\ub85c, \uae30\uc220, \uc720\ud1b5 \ucc44\ub110 \ubc0f \uc9c0\uc5ed\uc5d0 \ub530\ub77c \uae00\ub85c\ubc8c \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uc2dc\uc7a5\uc744 \uc138\ubd84\ud654\ud558\uace0 \uc8fc\uc694 \uc0c1\uc5c5 \uc790\uc0b0 \ubc0f \ud50c\ub808\uc774\uc5b4\ub97c \uc774\ud574\ud569\ub2c8\ub2e4.
                                                                        \n\ub3d9\ud5a5\uacfc \uacf5\ub3d9 \uac1c\ubc1c\uc744 \ubd84\uc11d\ud558\uc5ec \uc0c1\uc5c5\uc801 \uae30\ud68c\ub97c \ud30c\uc545\ud569\ub2c8\ub2e4.
                                                                        \n\ubaa8\ub4e0 \uc138\uadf8\uba3c\ud2b8\uac00 \ud3ec\ud568\ub41c \ub3d9\ud615\uc811\ud569 \uac00\uc871\uc131 \uace0\ucf5c\ub808\uc2a4\ud14c\ub864\ud608\uc99d \uc2dc\uc7a5 \uc218\uc900\uc758 \uc218\ub9ce\uc740 \ub370\uc774\ud130 \ud3ec\uc778\ud2b8\uac00 \ud3ec\ud568\ub41c Excel \ub370\uc774\ud130 \uc2dc\ud2b8.
                                                                        \nPDF \ubcf4\uace0\uc11c\ub294 \ucca0\uc800\ud55c \uc815\uc131\uc801 \uc778\ud130\ubdf0\uc640 \uc2ec\uce35 \uc5f0\uad6c\ub97c \uac70\uce5c \uc885\ud569\uc801\uc778 \ubd84\uc11d\uc73c\ub85c \uad6c\uc131\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.
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