{"id":19111,"date":"2025-01-16T13:30:52","date_gmt":"2025-01-16T13:30:52","guid":{"rendered":"https:\/\/www.mizuho.kr\/?p=4250"},"modified":"2026-09-06T22:11:06","modified_gmt":"2026-09-06T13:11:06","slug":"parp-inhibitors-market-datam","status":"publish","type":"post","link":"https:\/\/www.globalresearch.co.kr\/insight\/parp-inhibitors-market-datam\/","title":{"rendered":"\uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 : \uc81c\ud488 \uc720\ud615\ubcc4 (\uc62c\ub77c\ud30c\ub9bd, \ub2c8\ub77c\ud30c\ub9bd, \ub8e8\uce74\ud30c\ub9bd, \ud0c8\ub77c\uc870\ud30c\ub9bd, \uae30\ud0c0)"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4251\" src=\"https:\/\/www.mizuho.kr\/wp-content\/uploads\/2025\/01\/1-313.png\" alt=\"\" width=\"1354\" height=\"415\" \/><\/p>\n<p>&nbsp;<\/p>\n<ol>\n<li><b>\ubc29\ubc95\ub860 \ubc0f \ubc94\uc704<\/b>\n<ol>\n<li>\uc5f0\uad6c \ubc29\ubc95\ub860<\/li>\n<li>\ubcf4\uace0\uc11c\uc758 \uc5f0\uad6c \ubaa9\uc801 \ubc0f \ubc94\uc704<\/li>\n<\/ol>\n<\/li>\n<li><b>\uc815\uc758 \ubc0f \uac1c\uc694<\/b><\/li>\n<li><b>\uc784\uc6d0 \uc694\uc57d<\/b>\n<ol>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n<li>\uc560\ud50c\ub9ac\ucf00\uc774\uc158\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n<li>\uc720\ud1b5 \ucc44\ub110\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n<li>\uc9c0\uc5ed\ubcc4 \uc2a4\ub2c8\ud3ab<\/li>\n<\/ol>\n<\/li>\n<li><b>\uc5ed\ud559<\/b>\n<ol>\n<li>\uc601\ud5a5 \uc694\uc778\n<ol>\n<li>\ub3d9\uc778\n<ol>\n<li>\uc554 \ubc1c\uc0dd\ub960 \uc99d\uac00<\/li>\n<li>XX<\/li>\n<\/ol>\n<\/li>\n<li>\uc81c\uc57d\n<ol>\n<li>\uc57d\ubb3c \ub0b4\uc131<\/li>\n<\/ol>\n<\/li>\n<li>\uae30\ud68c<\/li>\n<li>\uc601\ud5a5 \ubd84\uc11d<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<li><b>\uc0b0\uc5c5 \ubd84\uc11d<\/b>\n<ol>\n<li>\ud3ec\ud130\uc758 5\uac00\uc9c0 \ud798 \ubd84\uc11d<\/li>\n<li>\uacf5\uae09\ub9dd \ubd84\uc11d<\/li>\n<li>\uac00\uaca9 \ubd84\uc11d<\/li>\n<li>\uaddc\uc81c \ubd84\uc11d<\/li>\n<\/ol>\n<\/li>\n<li><b>\uc81c\ud488 \uc720\ud615\ubcc4<\/b>\n<ol>\n<li>\uc18c\uac1c\n<ol>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218<\/li>\n<\/ol>\n<\/li>\n<li>\uc62c\ub77c\ud30c\ub9bd *\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<\/ol>\n<\/li>\n<li>\ub2c8\ub77c\ud30c\ub9bd<\/li>\n<li>\ub8e8\uce74\ud30c\ub9bd<\/li>\n<li>\ud0c8\ub77c\uc870\ud30c\ub9bd<\/li>\n<li>\uae30\ud0c0<\/li>\n<\/ol>\n<\/li>\n<li><b>\uc560\ud50c\ub9ac\ucf00\uc774\uc158\ubcc4<\/b>\n<ol>\n<li>\uc18c\uac1c\n<ol>\n<li>\uc560\ud50c\ub9ac\ucf00\uc774\uc158\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218, \uc560\ud50c\ub9ac\ucf00\uc774\uc158\ubcc4<\/li>\n<\/ol>\n<\/li>\n<li>\uc720\ubc29\uc554 *\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<\/ol>\n<\/li>\n<li>\ub09c\uc18c\uc554<\/li>\n<li>\uc804\ub9bd\uc120 \uc554<\/li>\n<li>\ub098\ud314\uad00 \uc554<\/li>\n<li>\ubcf5\ub9c9\uc554<\/li>\n<li>\uae30\ud0c0<\/li>\n<\/ol>\n<\/li>\n<li><b>\uc720\ud1b5 \ucc44\ub110\ubcc4<\/b>\n<ol>\n<li>\uc18c\uac1c\n<ol>\n<li>\uc720\ud1b5 \ucc44\ub110\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144\ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc720\ud1b5 \ucc44\ub110\ubcc4 \uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218<\/li>\n<\/ol>\n<\/li>\n<li>\ubcd1\uc6d0 \uc57d\uad6d *\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144\ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d (%)<\/li>\n<\/ol>\n<\/li>\n<li>\uc18c\ub9e4 \uc57d\uad6d<\/li>\n<li>\uc628\ub77c\uc778 \uc57d\uad6d<\/li>\n<\/ol>\n<\/li>\n<li><b>\uc9c0\uc5ed\ubcc4<\/b>\n<ol>\n<li>\uc18c\uac1c\n<ol>\n<li>\uc9c0\uc5ed\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc9c0\uc5ed\ubcc4 \uc2dc\uc7a5 \ub9e4\ub825\ub3c4 \uc9c0\uc218<\/li>\n<\/ol>\n<\/li>\n<li>\ubd81\ubbf8\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uc560\ud50c\ub9ac\ucf00\uc774\uc158 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%), \uad6d\uac00 \ubcc4\n<ol>\n<li>\ubbf8\uad6d<\/li>\n<li>\uce90\ub098\ub2e4<\/li>\n<li>\uba55\uc2dc\ucf54<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<li>\uc720\ub7fd\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc560\ud50c\ub9ac\ucf00\uc774\uc158 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uad6d\uac00 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)\n<ol>\n<li>\ub3c5\uc77c<\/li>\n<li>\uc601\uad6d<\/li>\n<li>\ud504\ub791\uc2a4<\/li>\n<li>\uc2a4\ud398\uc778<\/li>\n<li>\uc774\ud0c8\ub9ac\uc544<\/li>\n<li>\uae30\ud0c0 \uc720\ub7fd<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<li>\ub0a8\ubbf8\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc560\ud50c\ub9ac\ucf00\uc774\uc158 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uad6d\uac00 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)\n<ol>\n<li>\ube0c\ub77c\uc9c8<\/li>\n<li>\uc544\ub974\ud5e8\ud2f0\ub098<\/li>\n<li>\uae30\ud0c0 \ub0a8\ubbf8<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<li>\uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc560\ud50c\ub9ac\ucf00\uc774\uc158 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<li>\uad6d\uac00 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)\n<ol>\n<li>\uc911\uad6d<\/li>\n<li>\uc778\ub3c4<\/li>\n<li>\uc77c\ubcf8<\/li>\n<li>\ub300\ud55c\ubbfc\uad6d<\/li>\n<li>\uae30\ud0c0 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<li>\uc911\ub3d9 \ubc0f \uc544\ud504\ub9ac\uce74\n<ol>\n<li>\uc18c\uac1c<\/li>\n<li>\uc8fc\uc694 \uc9c0\uc5ed\ubcc4 \uc5ed\ud559 \uad00\uacc4<\/li>\n<li>\uc81c\ud488 \uc720\ud615\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc560\ud50c\ub9ac\ucf00\uc774\uc158\ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5\ub960 \ubd84\uc11d(%)<\/li>\n<li>\uc720\ud1b5 \ucc44\ub110 \ubcc4 \uc2dc\uc7a5 \uaddc\ubaa8 \ubd84\uc11d \ubc0f \uc804\ub144 \ub300\ube44 \uc131\uc7a5 \ubd84\uc11d (%)<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<li><b>\uacbd\uc7c1 \ud658\uacbd<\/b>\n<ol>\n<li>\uacbd\uc7c1 \uc2dc\ub098\ub9ac\uc624<\/li>\n<li>\uc2dc\uc7a5 \ud3ec\uc9c0\uc154\ub2dd\/\uc810\uc720\uc728 \ubd84\uc11d<\/li>\n<li>\uc778\uc218\ud569\ubcd1 \ubd84\uc11d<\/li>\n<\/ol>\n<\/li>\n<li><b>\uae30\uc5c5 \ud504\ub85c\ud544<\/b><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4252\" src=\"https:\/\/www.mizuho.kr\/wp-content\/uploads\/2025\/01\/2-218.png\" alt=\"\" width=\"1091\" height=\"616\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc740 2023\ub144\uc5d0 35.3\uc5b5 \ub2ec\ub7ec\uc5d0 \ub2ec\ud588\uc73c\uba70 2024-2031\ub144 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 8.3%\uc758 \uc5f0\ud3c9\uade0 \uc131\uc7a5\ub960\ub85c \uc131\uc7a5\ud558\uc5ec 2031\ub144\uc5d0\ub294 66.4\uc5b5 \ub2ec\ub7ec\uc5d0 \ub2ec\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\nPARP(\ud3f4\ub9ac ADP-\ub9ac\ubcf4\uc2a4 \uc911\ud569\ud6a8\uc18c) \ub2e8\ubc31\uc9c8\uc740 \ub04a\uc5b4\uc9c4 DNA \uac00\ub2e5\uc5d0 \uacb0\ud569\ud558\uace0 \uc190\uc0c1\ub41c DNA\uc758 \ubcf5\uad6c\ub97c \ucd09\uc9c4\ud558\uae30 \uc704\ud574 \ucd94\uac00 \ub2e8\ubc31\uc9c8\uc744 \ubaa8\uc9d1\ud558\ub294 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc5ec\ub7ec \uc720\uc804\uc790\uc5d0 \uc758\ud574 \uc9c0\ubc30\ub418\ub294 \ub2e4\uc591\ud55c \uacbd\ub85c\uac00 DNA \uc190\uc0c1 \ubcf5\uad6c\uc5d0 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. PARP \ub2e8\ubc31\uc9c8 \uacc4\uc5f4\uc740 \ud2b9\ud788 DNA\uc758 \ub2e8\uc77c \uac00\ub2e5 \ub04a\uc5b4\uc9d0\uc5d0 \ub300\ud55c \ubc18\uc751\uc744 \uc870\uc808\ud569\ub2c8\ub2e4. \uc774 \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uba74 \uc138\ud3ec\ub294 DNA \uc190\uc0c1\uc744 \ud574\uacb0\ud558\uae30 \uc704\ud574 \ub300\uccb4 \uba54\ucee4\ub2c8\uc998\uc5d0 \uc758\uc874\ud560 \uc218\ubc16\uc5d0 \uc5c6\uc2b5\ub2c8\ub2e4.<br \/>\nPARP \uc5b5\uc81c\uc81c\ub294 \uc138\ud3ec \ub0b4\uc5d0\uc11c DNA \uc190\uc0c1\uc744 \ubcf5\uad6c\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 PARP \ud6a8\uc18c\uc758 \uae30\ub2a5\uc744 \ubc29\ud574\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \uc57d\ubb3c\uc785\ub2c8\ub2e4. PARP \ud6a8\uc18c\ub294 \ud658\uacbd \uc2a4\ud2b8\ub808\uc2a4 \uc694\uc778 \ubc0f \uc815\uc0c1\uc801\uc778 \uc138\ud3ec \uacfc\uc815\uc744 \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc694\uc778\uc73c\ub85c \uc778\ud574 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub294 DNA\uc758 \ub2e8\uc77c \uac00\ub2e5 \ub04a\uae40\uc744 \ubcf5\uad6c\ud558\ub294 \ub370 \ud544\uc218\uc801\uc785\ub2c8\ub2e4. PARP\ub294 \uc190\uc0c1\ub41c DNA\ub97c \uac10\uc9c0\ud558\uace0 \ubcf5\uad6c\ud558\ub294 \ud6a8\uc18c\uc785\ub2c8\ub2e4. DNA\uac00 \uc190\uc0c1\ub418\uba74 PARP\ub294 \uc190\uc0c1\ub41c \ubd80\uc704\uc5d0 \uacb0\ud569\ud558\uc5ec \ubcf5\uad6c \uacfc\uc815\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e4\ub978 \ub2e8\ubc31\uc9c8\uc744 \ubaa8\uc9d1\ud558\uc5ec \ubcf5\uad6c\ub97c \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uc774\ub294 \uac8c\ub188 \uc548\uc815\uc131\uc744 \uc720\uc9c0\ud558\ub294 \ub370 \ud2b9\ud788 \uc911\uc694\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc694\uc778\uc73c\ub85c \uc778\ud574 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc774 \ud655\ub300\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc2dc\uc7a5 \uc5ed\ud559: \ub3d9\uc778 \ubc0f \uc81c\uc57d \uc694\uc778<br \/>\n\uc554 \ubc1c\uc0dd\ub960 \uc99d\uac00<br \/>\n\uc554 \ubc1c\uc0dd\ub960\uc758 \uc99d\uac00\ub294 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc758 \uc131\uc7a5\uc744 \ud06c\uac8c \uacac\uc778\ud558\uace0 \uc788\uc73c\uba70, \uc774\ub7ec\ud55c \ucd94\uc138\ub294 \uc2dc\uc7a5 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uacc4\uc18d\ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\uc554 \ubc1c\uc0dd\ub960 \uc99d\uac00\ub294 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc744 \ucd94\uc9c4\ud558\ub294 \ud575\uc2ec \uc694\uc778\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc131\uc7a5\uc740 \ud658\uc790 \uc218 \uc99d\uac00, \uc720\uc804\uc790 \uac80\uc0ac\uc758 \uac1c\uc120, \ud45c\uc801 \uce58\ub8cc\ubc95\uc5d0 \ub300\ud55c \uc218\uc694 \uc99d\uac00, \uc0ac\uc6a9 \uac00\ub2a5\ud55c \uce58\ub8cc \uc635\uc158\uc5d0 \ub300\ud55c \uc778\uc2dd \ud5a5\uc0c1\uc5d0 \uc758\ud574 \ucd09\uc9c4\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. PARP \uc5b5\uc81c\uc81c\ub85c \ud6a8\uacfc\uc801\uc73c\ub85c \uad00\ub9ac\ud560 \uc218 \uc788\ub294 \uc554 \uc9c4\ub2e8\uc744 \ubc1b\ub294 \uc0ac\ub78c\uc774 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \uc885\uc591\ud559 \ubd84\uc57c\uc758 \uac1c\uc778 \ub9de\ucda4\ud615 \uc758\uc57d\ud488 \uc2dc\uc7a5\uc740 \ud06c\uac8c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n2022\ub144 \ubbf8\uad6d \uc554 \ud611\ud68c \ub370\uc774\ud130\uc5d0 \ub530\ub974\uba74, \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uc57d 2,000\ub9cc \uac74\uc758 \uc0c8\ub85c\uc6b4 \uc554\uc774 \uc9c4\ub2e8\ub418\uc5c8\uace0, \uc774\ub85c \uc778\ud574 970\ub9cc \uba85\uc774 \uc554\uc73c\ub85c \uc0ac\ub9dd\ud588\uc2b5\ub2c8\ub2e4. 2050\ub144\uc5d0\ub294 \uc774 \uc218\uce58\uac00 3,500\ub9cc \uac74\uc73c\ub85c \uc99d\uac00\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uba70, \uc774\ub294 \ud604\uc7ac \ubc1c\ubcd1\ub960\uc774 \uadf8\ub300\ub85c \uc720\uc9c0\ub41c\ub2e4\uace0 \uac00\uc815\ud560 \ub54c \uc608\uc0c1\ub418\ub294 \uc778\uad6c \uc99d\uac00\uc728\ub9cc\uc744 \uae30\uc900\uc73c\ub85c 77% \uc99d\uac00\ud55c \uc218\uce58\uc785\ub2c8\ub2e4. \uc774\ucc98\ub7fc \uc554 \ubc1c\uc0dd \uac74\uc218\uac00 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c PARP \uc5b5\uc81c\uc81c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<br \/>\n\uc790\uad81\ub0b4\ub9c9\uc554\uc740 \uc790\uad81 \ub0b4\ub9c9 \uc870\uc9c1\uc5d0\uc11c \uc2dc\uc791\ub418\ub294 \ub9e4\uc6b0 \ub2e4\uc591\ud55c \uc9c8\ud658\uc73c\ub85c \ud3d0\uacbd \ud6c4 \uc5ec\uc131\uc5d0\uc11c \uac00\uc7a5 \ud754\ud558\uac8c \uc9c4\ub2e8\ub418\uba70 \ud3c9\uade0 \uc9c4\ub2e8 \uc5f0\ub839\uc740 60\uc138\ub97c \ub118\uc2b5\ub2c8\ub2e4. \uc720\ub7fd\uc5d0\uc11c \uc790\uad81\ub0b4\ub9c9\uc554\uc740 \uc5ec\uc131\uc5d0\uac8c \ub124 \ubc88\uc9f8\ub85c \ub9ce\uc774 \ubc1c\uc0dd\ud558\ub294 \uc554\uc73c\ub85c, 2022\ub144\uc5d0 \uc57d 12\ub9cc 5,000\uac74\uc758 \uc0c8\ub85c\uc6b4 \ubc1c\ubcd1 \uc0ac\ub840\uc640 3\ub9cc \uba85 \uc774\uc0c1\uc758 \uc0ac\ub9dd\uc790\uac00 \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc870\uae30\uc5d0 \uc9c4\ub2e8\ub41c \ud658\uc790\uc758 5\ub144 \uc0dd\uc874\uc728\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uc57d 80~90%\uc774\uc9c0\ub9cc, \ubcd1\uc774 \uc9c4\ud589\ub41c \ud658\uc790\uc758 \uacbd\uc6b0 \uc0dd\uc874\uc728\uc774 20% \uc774\ud558\ub85c \ub5a8\uc5b4\uc9d1\ub2c8\ub2e4. \ud2b9\ud788 \uc219\ub828\ub41c \ubd88\uc77c\uce58 \ubcf5\uad6c(pMMR) \uc9c8\ud658\uc744 \uac00\uc9c4 70~80%\uc758 \ud658\uc790\ub97c \uc704\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc635\uc158\uc774 \uc808\uc2e4\ud788 \uc694\uad6c\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\ub300\ubd80\ubd84\uc758 \ud658\uc790\ub294 \uc554\uc774 \uc790\uad81\uc5d0 \uad6d\ud55c\ub41c \ucd08\uae30 \ub2e8\uacc4\uc5d0\uc11c \uc9c4\ub2e8\ub418\uba70, \uc77c\ubc18\uc801\uc73c\ub85c \uc218\uc220 \ubc0f\/\ub610\ub294 \ubc29\uc0ac\uc120 \uce58\ub8cc\ub97c \ubc1b\uc544 5\ub144 \uc0dd\uc874\uc728\uc774 \uc57d 80~90%\uc5d0 \uc774\ub985\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc9c4\ud589\uc131(3\uae30~4\uae30) \uc790\uad81\ub0b4\ub9c9\uc554 \ud658\uc790\uc758 \uacbd\uc6b0 5\ub144 \uc0dd\uc874\uc728\uc774 20% \ubbf8\ub9cc\uc73c\ub85c \ub5a8\uc5b4\uc9c0\ub294 \ub4f1 \uc608\ud6c4\uac00 \ud604\uc800\ud788 \ub098\uc069\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubaa8\ub4e0 \uc694\uc778\uc774 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc744 \uc694\uad6c\ud569\ub2c8\ub2e4.<br \/>\n\ub610\ud55c \ubcd1\uc6a9 \uc694\ubc95\uc5d0 \ub300\ud55c \uc218\uc694 \uc99d\uac00\ub294 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc758 \ud655\ub300\uc5d0 \uae30\uc5ec\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\uc57d\ubb3c\uc758 \ub0b4\uc131<br \/>\n\uc57d\ubb3c\uc758 \ub0b4\uc131\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c\uc758 \uc131\uc7a5\uc744 \ubc29\ud574 \ud560 \uac83\uc785\ub2c8\ub2e4. PARP \uc5b5\uc81c\uc81c\ub294 \ud6a8\uacfc\uc801\uc778 \uc554 \uce58\ub8cc\ubc95\uc774\uc9c0\ub9cc, \uce58\ub8cc\ud560 \uc218 \uc788\ub294 \uc554\uc758 \ud2b9\uc815 \uc720\ud615\uacfc \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \ub0b4\uc131\uc774 \ubc1c\uc0dd\ud560 \uac00\ub2a5\uc131 \ub4f1 \ud2b9\uc815 \uc81c\ud55c \uc0ac\ud56d\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub9ac\ud2bc\uc5d0 \ub530\ub974\uba74 2024\ub144 4\uc6d4 MD \uc564\ub354\uc2a8 \uc554\uc13c\ud130 \uc5f0\uad6c \ubc1c\ud45c\uc5d0 \ub530\ub974\uba74, \ub0b4\uc131\uc744 \ud574\uacb0\ud558\uace0 \uce58\ub8cc \ubc18\uc751\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uae30 \uc704\ud574 \ub354 \uad11\ubc94\uc704\ud55c \uc885\uc591\uacfc \ub2e4\uc591\ud55c DNA \ubcf5\uad6c \uacb0\ud568\uc73c\ub85c \uc0ac\uc6a9\uc744 \ud655\ub300\ud558\uae30 \uc704\ud574 PARP \uc5b5\uc81c\uc81c\ub97c \ub2e4\ub978 \uce58\ub8cc\uc81c\uc640 \uc870\ud569\ud558\ub294 \uc5ec\ub7ec \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4.<br \/>\nPARP \uc5b5\uc81c\uc81c\uc758 \uc77c\ubc18\uc801\uc778 \ubb38\uc81c\ub294 \ud658\uc790\ub4e4\uc774 \uacb0\uad6d \ub0b4\uc131\uc774 \uc0dd\uaca8 \uc57d\ubb3c\uc758 \uc7a5\uae30\uc801\uc778 \ud6a8\uacfc\uac00 \uac10\uc18c\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 \ud658\uc790 \uc0d8\ud50c\uc744 \uc870\uc0ac\ud558\uc5ec \uc554\uc138\ud3ec\uac00 \uc774\ub7ec\ud55c \ub0b4\uc131\uc744 \uc5bb\ub294 \ubc29\ubc95\uc744 \uc774\ud574\ud558\uace0 \ud658\uc790\uc758 \ub0b4\uc131 \ubc1c\uc0dd \uac00\ub2a5\uc131\uc744 \ub098\ud0c0\ub0bc \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \uc2dd\ubcc4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\ub610\ud55c \uc5f0\uad6c\uc790\ub4e4\uc740 \ub0b4\uc131\uc744 \uadf9\ubcf5\ud558\uace0 \uce58\ub8cc \uacb0\uacfc\ub97c \uac1c\uc120\ud558\uae30 \uc704\ud574 PARP \uc5b5\uc81c\uc81c\uc640 \ubcd1\uc6a9\ud560 \uc218 \uc788\ub294 \ub2e4\ub978 \ud45c\uc801 \uce58\ub8cc\ubc95\uc744 \ubaa8\uc0c9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc720\ub9dd\ud55c \uc811\uadfc\ubc95 \uc911 \ud558\ub098\ub294 DNA\uc640 \uc0c1\ud638 \uc791\uc6a9\ud558\ub294 PRMT \uc5b5\uc81c\uc81c\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc73c\ub85c, \uc608\ube44 \uc5f0\uad6c\uc5d0\uc11c PARP \uc5b5\uc81c\uc81c\uc640 \ubcd1\uc6a9\ud588\uc744 \ub54c \uace0\ubb34\uc801\uc778 \uacb0\uacfc\ub97c \ubcf4\uc778 \ubc14 \uc788\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc704\uc758 \uc694\uc778\ub4e4\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc758 \uc7a0\uc7ac\uc801 \uc131\uc7a5\uc744 \uc81c\ud55c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\uc2dc\uc7a5 \uc138\ubd84 \ubd84\uc11d<br \/>\n\uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc740 \uc81c\ud488 \uc720\ud615, \uc751\uc6a9 \ubd84\uc57c, \uc720\ud1b5 \ucc44\ub110 \ubc0f \uc9c0\uc5ed\uc5d0 \ub530\ub77c \uc138\ubd84\ud654\ub429\ub2c8\ub2e4.<br \/>\n\uc81c\ud488 \uc720\ud615:<br \/>\n\uc62c\ub77c\ud30c\ub9bd \ubd80\ubb38\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc744 \uc9c0\ubc30 \ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\uc62c\ub77c\ud30c\ub9bd \ubd80\ubb38\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 \ub300\ubd80\ubd84\uc744 \ucc28\uc9c0\ud558\uace0 \uc788\uc73c\uba70 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc744 \uacc4\uc18d \ucc28\uc9c0\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\ub9b0\ud30c\uc790(\uc62c\ub77c\ud30c\ub9bd)\ub294 \uc120\uad6c\uc801\uc778 \ucd5c\ucd08\uc758 PARP \uc5b5\uc81c\uc81c\uc774\uc790 \uc0c1\ub3d9 \uc7ac\uc870\ud569 \ubcf5\uad6c(HRR) \uacb0\ud568\uc744 \ubcf4\uc774\ub294 \uc138\ud3ec \ub610\ub294 \uc885\uc591, \ud2b9\ud788 BRCA1 \ub610\ub294 BRCA2 \uc720\uc804\uc790(BRCAm)\uc5d0 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc788\ub294 \uc885\uc591\uc758 DNA \uc190\uc0c1 \ubc18\uc751(DDR)\uc744 \ucc28\ub2e8\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \ucd5c\ucd08\uc758 \ud45c\uc801 \uce58\ub8cc\uc81c\ub85c, \ud2b9\ud788 BRCA1 \uc720\uc804\uc790\uc5d0 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc788\ub294 \uc885\uc591\uc5d0 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc720\uc804\uc790\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub294 \uc0c1\ub3d9 \uc7ac\uc870\ud569 \uacb0\ud54d(HRD)\uc73c\ub85c \uc774\uc5b4\uc9c0\uba70, \uc774\ub294 \ud2b9\uc815 \uc554 \ubc1c\ubcd1 \uc704\ud5d8 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc73c\uba70 \ub354 \uacf5\uaca9\uc801\uc778 \uc9c8\ubcd1 \uc9c4\ud589\uc744 \ucd08\ub798\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n2024\ub144 7\uc6d4 MJH \ub77c\uc774\ud504 \uc0ac\uc774\uc5b8\uc2a4 \uae30\uc0ac\uc5d0 \ub530\ub974\uba74, \ud2b9\uc815 \uc554 \uce58\ub8cc\ub97c \uc704\ud574 FDA\uc758 \uc2b9\uc778\uc744 \ubc1b\uc740 \ucd5c\ucd08\uc758 PARP \uc5b5\uc81c\uc81c\uc778 \ub9b0\ud30c\uc790(\uc62c\ub77c\ud30c\ub9bd)\ub294 \uc9c0\ub09c 10\ub144\uac04 \uc57d 45,500\uba85\uc758 \ud658\uc790\uc5d0\uac8c \ucc98\ubc29\ub418\uc5b4 \ubbf8\ucda9\uc871 \uc758\ub8cc \uc218\uc694\uac00 \ud070 \uac1c\uc778\uc5d0\uac8c \ud45c\uc801 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4. \ub9b0\ud30c\uc790\uac00 \uac1c\uc778 \ub9de\ucda4\ud615 \uc885\uc591 \uc758\ud559\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc5d0 \ub300\ud55c \uc778\uc0ac\uc774\ud2b8\ub97c \uc5bb\uc73c\ub824\uba74. \uc774\ub7ec\ud55c \uc694\uc778\ub4e4\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uc774 \ubd80\ubb38\uc758 \uc785\uc9c0\ub97c \uacf5\uace0\ud788 \ud588\uc2b5\ub2c8\ub2e4.<br \/>\n\ub2c8\ub77c\ud30c\ub9bd \ubd80\ubb38\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc5d0\uc11c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \ubd80\ubb38\uc785\ub2c8\ub2e4.<br \/>\n\ub2c8\ub77c\ud30c\ub9bd \uc138\uadf8\uba3c\ud2b8\ub294 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc5d0\uc11c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \uc138\uadf8\uba3c\ud2b8\uc774\uba70 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uc2dc\uc7a5 \uc810\uc720\uc728\uc744 \uc720\uc9c0\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\ub2c8\ub77c\ud30c\ub9bd\uc740 \ud604\uc7ac \uc804\uc774\uc131 \uac70\uc138 \uc800\ud56d\uc131 \uc804\ub9bd\uc120\uc554(mCRPC) \ud658\uc790, \ud2b9\ud788 BRCA1 \ub610\ub294 BRCA2 DNA \ubcf5\uad6c \uc720\uc804\uc790\uc5d0 \uacb0\ud568\uc774 \uc788\ub294 \ud658\uc790\uc758 \uce58\ub8cc\ub97c \uc704\ud574 \uc5f0\uad6c \uc911\uc778 \uacbd\uad6c \ud22c\uc5ec\uc6a9 PARP \uc5b5\uc81c\uc81c\uc785\ub2c8\ub2e4.<br \/>\n\ub2c8\ub77c\ud30c\ub9bd\uc740 DNA \uc190\uc0c1 \ubcf5\uad6c\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e8\ubc31\uc9c8\uc778 \ud3f4\ub9ac(ADP-\ub9ac\ubcf4\uc2a4) \uc911\ud569\ud6a8\uc18c(PARP)\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \ubc29\uc2dd\uc73c\ub85c \uc791\uc6a9\ud569\ub2c8\ub2e4. \ub2c8\ub77c\ud30c\ub9bd\uc740 PARP\ub97c \ucc28\ub2e8\ud568\uc73c\ub85c\uc368 \uc554\uc138\ud3ec\uac00 DNA\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ubcf5\uad6c\ud558\uc9c0 \ubabb\ud558\uac8c \ud558\uc5ec DNA \uc190\uc0c1\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 \uad81\uadf9\uc801\uc73c\ub85c \uc138\ud3ec \uc0ac\uba78\ub85c \uc774\uc5b4\uc9c0\uac8c \ud569\ub2c8\ub2e4. \uc774 \uba54\ucee4\ub2c8\uc998\uc740 \uc804\ub9bd\uc120\uc554\uc744 \ud3ec\ud568\ud55c \ud2b9\uc815 \uc554\uc5d0\uc11c \ud754\ud788 \ubc1c\uc0dd\ud558\ub294 BRCA \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc778\ud55c \uac83\uacfc \uac19\uc740 \uc0c1\ub3d9 \uc7ac\uc870\ud569 \uacb0\ud54d(HRD)\uc774 \uc788\ub294 \uc885\uc591\uc5d0 \ud2b9\ud788 \ud6a8\uacfc\uc801\uc785\ub2c8\ub2e4.<br \/>\n\ub610\ud55c, \uc5c5\uacc4 \uc8fc\uc694 \uc5c5\uccb4\ub4e4\uc758 \uc81c\ud488 \ucd9c\uc2dc \ubc0f \uc2b9\uc778\uc740 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uc774 \ubd80\ubb38\uc758 \uc131\uc7a5\uc744 \ucd09\uc9c4\ud560 \uac83\uc785\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, 2023\ub144 8\uc6d4 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc740 \ub2c8\ub77c\ud30c\ub9bd\uacfc \uc544\ube44\ub77c\ud14c\ub860 \uc544\uc138\ud14c\uc774\ud2b8\ub97c \uacb0\ud569\ud55c \uc774\uc911 \uc791\uc6a9 \uc815\uc81c\uc778 AKEEGA\ub97c BRCA \uc591\uc131 \uc804\uc774\uc131 \uac70\uc138 \uc800\ud56d\uc131 \uc804\ub9bd\uc120\uc554(mCRPC) \ud658\uc790 \uce58\ub8cc\ub97c \uc704\ud574 \uc2b9\uc778\ud588\uc2b5\ub2c8\ub2e4. \uc774\ubc88 \uc2b9\uc778\uc73c\ub85c \uc544\ucf00\uac00\ub294 BRCA \ub3cc\uc5f0\ubcc0\uc774\uc640 \uad00\ub828\ub41c \uc554 \ud658\uc790\uc758 \ud2b9\uc815 \uc694\uad6c\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud574 \uace0\uc548\ub41c \ucd5c\ucd08\uc774\uc790 \uc720\uc77c\ud55c \uc57d\ubb3c\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc694\uc778\uc73c\ub85c \uc778\ud574 \uc804 \uc138\uacc4 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uc774 \ubd80\ubb38\uc758 \uc785\uc9c0\uac00 \ub354\uc6b1 \uacf5\uace0\ud574\uc84c\uc2b5\ub2c8\ub2e4.<br \/>\n\uc751\uc6a9 \ubd84\uc57c :<br \/>\n\ub09c\uc18c \uc554 \ubd80\ubb38\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc744 \uc9c0\ubc30 \ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\ub09c\uc18c \uc554 \ubd80\ubb38\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 \uc8fc\uc694 \ubd80\ubd84\uc744 \ucc28\uc9c0\ud558\uace0 \uc788\uc73c\uba70 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc744 \uacc4\uc18d \ucc28\uc9c0\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\ub09c\uc18c\uc554\uc740 \ubbf8\uad6d\uc5d0\uc11c \uac00\uc7a5 \ud754\ud558\uace0 \uce58\uba85\uc801\uc778 \ubd80\uc778\uacfc \uc554 \uc911 \ud558\ub098\ub85c, 5\ub144 \uc0c1\ub300 \uc0dd\uc874\uc728\uc774 51%\uc5d0 \ub2ec\ud569\ub2c8\ub2e4. \ub09c\uc18c\uc554 \ud658\uc790\uc758 3\ubd84\uc758 2 \uc774\uc0c1\uc774 \uc9c4\ud589\uc131 \ub09c\uc18c\uc554\uc73c\ub85c \uc9c4\ub2e8\ub418\uae30 \ub54c\ubb38\uc5d0 \uc9c4\ud589\uc131 \ub09c\uc18c\uc554\uc73c\ub85c \uc9c4\ub2e8\ub41c \ud658\uc790\uc758 \uc0dd\uc874\uc728\uc740 \uc774\ubcf4\ub2e4 \ub354 \ub0ae\uc544\uc838 \uc57d 31%\ub85c \ucd94\uc815\ub429\ub2c8\ub2e4.<br \/>\n\uc9c4\ud589\uc131 \ub09c\uc18c\uc554 \uc5ec\uc131\uc758 \uc57d 20%\ub294 BRCA \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \uc57d \uc808\ubc18\uc740 \uc885\uc591\uc5d0 \uc0c1\ub3d9 \uc7ac\uc870\ud569 \uacb0\ud54d(HRD) \uc591\uc131 \ubc18\uc751\uc744 \ubcf4\uc774\ub294\ub370, \uc5ec\uae30\uc5d0\ub294 BRCA \ub3cc\uc5f0\ubcc0\uc774\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4. \uc9c4\ud589\uc131 \ub09c\uc18c\uc554\uc758 \uc608\ud6c4\uac00 \uc88b\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0 \uc0c8\ub86d\uace0 \uac1c\uc120\ub41c \uce58\ub8cc \uc635\uc158\uc5d0 \ub300\ud55c \ubbf8\ucda9\uc871 \uc218\uc694\uac00 \uc0c1\ub2f9\ud569\ub2c8\ub2e4. \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ub530\ub974\uba74 \ub9b0\ud30c\uc790(\uc62c\ub77c\ud30c\ub9bd)\ub294 \ud2b9\uc815 \ubc14\uc774\uc624\ub9c8\ucee4\uc5d0 \ub530\ub77c \uc120\ubcc4\ub41c \uc9c4\ud589\uc131 \ub09c\uc18c\uc554 \ud658\uc790\uc5d0\uc11c \ubb34\uc9c4\ud589 \uc0dd\uc874\uc728\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ub192\uc77c \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<br \/>\n2023\ub144 1\uc6d4\uc5d0 \ubc1c\ud45c\ub41c \ub09c\uc18c \uc5f0\uad6c \uc800\ub110\uc5d0 \ub530\ub974\uba74, \ud658\uc790 \uc720\ub798 \uc624\uac00\ub178\uc774\ub4dc(PDO)\uc758 \uc0ac\uc6a9\uc740 \ub09c\uc18c\uc554 \ud658\uc790\uc758 PARP \uc5b5\uc81c\uc81c \uc120\ud0dd\uacfc \uc57d\ubb3c \ub0b4\uc131 \ud574\uacb0\uc744 \uc704\ud55c \uc720\ub9dd\ud55c \uc885\uc591 \ubaa8\ub378\ub85c \ubd80\uc0c1\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. PDO\ub97c \uc0ac\uc6a9\ud558\uba74 \uc0c1\ud53c\uc131 \ub09c\uc18c\uc554(EOC)\uc5d0\uc11c PARP \uc5b5\uc81c\uc81c\uc5d0 \ub300\ud55c \ubc18\uc751\uc744 \uc608\uce21\ud560 \uc218 \uc788\ub294 \ubc14\uc774\uc624\ub9c8\ucee4\uc758 \uae30\ub2a5 \ud14c\uc2a4\ud2b8\ub97c \uc218\ud589\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc774 \ubaa8\ub378 \uc2dc\uc2a4\ud15c\uc740 DNA \ubcf5\uad6c \uacb0\ud54d\uc744 \ud2b9\uc9d5\uc73c\ub85c \ud558\ub294 \ub09c\uc18c\uc554\uc744 \ud3c9\uac00\ud558\ub294 \ub370 \ud6a8\uacfc\uc801\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4. \uc784\uc0c1\uc758\ub294 PDO\ub97c \ucc28\uc138\ub300 \uc2dc\ud000\uc2f1 \uac8c\ub188 \ubd84\uc11d\uacfc \ud1b5\ud569\ud558\uc5ec PARP \uc5b5\uc81c\uc81c \uce58\ub8cc\uc5d0 \uc801\ud569\ud55c \ud658\uc790\ub97c \uc2dd\ubcc4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc811\uadfc \ubc29\uc2dd\uc740 \uc784\uc0c1 \uc758\uc0ac\uacb0\uc815\uc744 \ub3d5\uace0 \ud658\uc790\uc758 \uc0dd\uc874 \uae30\uac04\uc744 \uc5f0\uc7a5\ud560 \uc218 \uc788\ub294 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc694\uc778\uc73c\ub85c \uc778\ud574 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uc774 \ubd80\ubb38\uc758 \uc785\uc9c0\uac00 \ud655\uace0\ud574\uc84c\uc2b5\ub2c8\ub2e4.<br \/>\n\uc720\ubc29\uc554 \ubd80\ubb38\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc5d0\uc11c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \ubd80\ubb38\uc785\ub2c8\ub2e4.<br \/>\n\uc720\ubc29\uc554 \ubd80\ubb38\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc5d0\uc11c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \ubd80\ubb38\uc774\uba70 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 \uc2dc\uc7a5 \uc810\uc720\uc728\uc744 \uc720\uc9c0\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\nPARP \uc5b5\uc81c\uc81c\ub294 \uc720\ubc29\uc554, \ub09c\uc18c\uc554, \uc804\ub9bd\uc120\uc554 \ub4f1 \ub2e4\uc591\ud55c \uc720\ud615\uc758 \uc554\uc744 \uce58\ub8cc\ud558\ub294 \ub370 \uc0ac\uc6a9\ub418\ub294 \ud45c\uc801 \uc554 \uce58\ub8cc\uc81c\uc758 \uc77c\uc885\uc785\ub2c8\ub2e4. \ub610\ud55c \ud604\uc7ac \ub2e4\ub978 \uc554 \uc720\ud615\uc5d0 \ub300\ud55c \uc7a0\uc7ac\uc801 \uc0ac\uc6a9\uc744 \uc704\ud574 \uc784\uc0c1 \uc2dc\ud5d8\uc774 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4.<br \/>\nPARP \uc5b5\uc81c\uc81c\ub294 BRCA1 \ub610\ub294 BRCA2 \uc720\uc804\uc790\uc5d0 \uc720\uc804\uc801 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc788\ub294 \uc0ac\ub78c\uc5d0\uac8c \ud2b9\ud788 \uc720\ub9dd\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub3cc\uc5f0\ubcc0\uc774\uc640 \uad00\ub828\ub41c \uc554\uc740 \uc885\uc885 DNA\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ubcf5\uad6c\ud558\ub294 \ub370 \uc5b4\ub824\uc6c0\uc744 \uacaa\uae30 \ub54c\ubb38\uc5d0 PARP \uc5b5\uc81c\uc81c\uc5d0 \uc758\ud574 \uc720\ubc1c\ub418\ub294 DNA \uc190\uc0c1\uc5d0 \ubbfc\uac10\ud569\ub2c8\ub2e4. BRCA1\/2 \uad00\ub828 \uc720\ubc29\uc554\uc744 PARP \uc5b5\uc81c\uc81c\ub85c \uce58\ub8cc\ud558\uba74 \uc554\uc138\ud3ec\uac00 \uc2a4\uc2a4\ub85c \ubcf5\uad6c\ud558\ub294 \uac83\uc774 \uc810\uc810 \ub354 \uc5b4\ub824\uc6cc\uc838 \uacb0\uad6d \uc0ac\ub9dd\uc5d0 \uc774\ub974\uac8c \ub429\ub2c8\ub2e4.<br \/>\n\uc62c\ub77c\ud30c\ub9bd(\uc131\ubd84\uba85: \ub9b0\ud30c\uc790)\uc740 BRCA1 \ub610\ub294 BRCA2(BRCA1\/2) \uc720\uc804\uc801 \uc720\uc804\uc790 \ubcc0\uc774\uac00 \uc788\uace0 \ud654\ud559 \uc694\ubc95\uc744 \ubc1b\uc740 \uc801\uc774 \uc788\ub294 \uc7ac\ubc1c \uc704\ud5d8\uc774 \ub192\uc740 \ud658\uc790\uc758 HER2 \uc74c\uc131 \uc870\uae30 \uc720\ubc29\uc554 \uce58\ub8cc\uc81c\ub85c FDA \uc2b9\uc778\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 \uc62c\ub77c\ud30c\ub9bd\uc73c\ub85c \uce58\ub8cc\ubc1b\uc740 BRCA1\/2 \ubcc0\uc774 \ubc0f HER2 \uc74c\uc131 \uc720\ubc29\uc554 \ud658\uc790\ub294 \uc57d\ubb3c\uc744 \ud22c\uc5ec\ubc1b\uc9c0 \uc54a\uc740 \ud658\uc790\uc5d0 \ube44\ud574 \uc554 \uc7ac\ubc1c \uc704\ud5d8\uc774 \uac10\uc18c\ud558\uace0 \uc0dd\uc874\uc728\uc774 \uac1c\uc120\ub41c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uc62c\ub77c\ud30c\ub9bd\uc740 \ud56d\uc554\ud654\ud559\uc694\ubc95 \uc885\ub8cc \ud6c4 \ud22c\uc5ec\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc694\uc778\uc73c\ub85c \uc778\ud574 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uc774 \ubd80\ubb38\uc758 \uae00\ub85c\ubc8c \uc785\uc9c0\uac00 \uacf5\uace0\ud574\uc84c\uc2b5\ub2c8\ub2e4.<br \/>\n\uc2dc\uc7a5 \uc9c0\ub9ac\uc801 \uc810\uc720\uc728<br \/>\n\ubd81\ubbf8\ub294 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc810\uc720\uc728\uc5d0\uc11c \uc911\uc694\ud55c \uc704\uce58\ub97c \ucc28\uc9c0\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\ubd81\ubbf8\ub294 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uc0c1\ub2f9\ud55c \uc704\uce58\ub97c \ucc28\uc9c0\ud558\uace0 \uc788\uc73c\uba70 \ub300\ubd80\ubd84\uc758 \uc2dc\uc7a5 \uc810\uc720\uc728\uc744 \ucc28\uc9c0\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\ud2b9\ud788 \uc720\ubc29\uc554, \ub09c\uc18c\uc554, \uc804\ub9bd\uc120\uc554\uacfc \uac19\uc740 BRCA \ub3cc\uc5f0\ubcc0\uc774\uc640 \uad00\ub828\ub41c \uc554\uc758 \uc720\ubcd1\ub960\uc740 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc758 \uc131\uc7a5\uc5d0 \ud070 \uae30\uc5ec\ub97c \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.  2023\ub144 8\uc6d4 Johnson &amp; Johnson \ub274\uc2a4\uc5d0 \ub530\ub974\uba74 \uc804\ub9bd\uc120\uc554\uc740 \ubbf8\uad6d\uc5d0\uc11c \uac00\uc7a5 \ud754\ud55c \uc554 \uc911 \ud558\ub098\ub85c, 2023\ub144\uc5d0 \uc57d 288,300\uba85\uc758 \uc2e0\uaddc \ud658\uc790\uac00 \ubc1c\uc0dd\ud558\uace0 \uc57d 35,000\uba85\uc774 \uc0ac\ub9dd\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\uc804\uc774\uc131 \uac70\uc138 \uc800\ud56d\uc131 \uc804\ub9bd\uc120\uc554(mCRPC) \ud658\uc790 \uc911 \uc57d 10~15%\ub294 BRCA1 \ub610\ub294 BRCA2 \uc720\uc804\uc790\uc5d0 \ubcc0\uc774\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub3cc\uc5f0\ubcc0\uc774\ub294 \ub354 \uacf5\uaca9\uc801\uc778 \ud615\ud0dc\uc758 \uc9c8\ubcd1\uacfc \uad00\ub828\uc774 \uc788\uc73c\uba70, \uc601\ud5a5\uc744 \ubc1b\ub294 \ud658\uc790\uc758 \uc608\ud6c4\uac00 \ub098\ube60\uc9c0\uace0 \uc0dd\uc874 \uae30\uac04\uc774 \uc9e7\uc544\uc9c0\uae30 \ub54c\ubb38\uc5d0 \uc911\uc694\ud569\ub2c8\ub2e4.<br \/>\n\ub610\ud55c\uc774 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \uc8fc\uc694 \ud50c\ub808\uc774\uc5b4\uc758 \uc874\uc7ac, \uc798 \ubc1c\ub2ec \ub41c \uc758\ub8cc \uc778\ud504\ub77c, \uc815\ubd80 \uc774\ub2c8\uc154\ud2f0\ube0c \ubc0f \uaddc\uc81c \uc9c0\uc6d0, \uae30\uc220 \ubc1c\uc804 \ubc0f \ud22c\uc790, \uc81c\ud488 \ucd9c\uc2dc \ubc0f \uc2b9\uc778\uc774\uc774 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc131\uc7a5\uc744 \ucd09\uc9c4 \ud560 \uac83\uc785\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, 2023\ub144 3\uc6d4 \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74\uc640 \uba38\ud06c\ub294 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc774 \ud56d\uc554\uc81c \uc790\ubb38\uc704\uc6d0\ud68c(ODAC) \ud68c\uc758\ub97c \uac1c\ucd5c\ud558\uc5ec \ub9b0\ud30c\uc790(\uc62c\ub77c\ud30c\ub9bd)\uc758 \ucd94\uac00 \uc2e0\uc57d \uc2e0\uccad(sNDA)\uc744 \ub17c\uc758\ud560 \uc608\uc815\uc774\ub77c\uace0 \ubc1c\ud45c\ud588\uc2b5\ub2c8\ub2e4.<br \/>\n\uc774 \uc2e0\uccad\uc740 \uc804\uc774\uc131 \uac70\uc138 \uc800\ud56d\uc131 \uc804\ub9bd\uc120\uc554(mCRPC) \uc131\uc778 \ud658\uc790\ub97c \uce58\ub8cc\ud558\uae30 \uc704\ud574 \uc544\ube44\ub77c\ud14c\ub860 \ubc0f \ud504\ub808\ub4dc\ub2c8\uc190 \ub610\ub294 \ud504\ub808\ub4dc\ub2c8\uc194\ub860\uacfc \ud568\uaed8 \ub9b0\ud30c\uc790\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc5d0 \ub300\ud55c \uc2b9\uc778\uc744 \uc694\uccad\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc704\uc758 \uc694\uc778\uc73c\ub85c \uc778\ud574 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc740 \uc804 \uc138\uacc4 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uc9c0\ubc30\uc801\uc778 \uc9c0\uc5ed\uc73c\ub85c \uc785\uc9c0\ub97c \uacf5\uace0\ud788 \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uac00\uc7a5 \ube60\ub978 \uc18d\ub3c4\ub85c \uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc740 \uc804 \uc138\uacc4 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uac00\uc7a5 \ube60\ub978 \uc18d\ub3c4\ub85c \uc131\uc7a5\ud558\uace0 \uc788\uc73c\uba70 \ub300\ubd80\ubd84\uc758 \uc2dc\uc7a5 \uc810\uc720\uc728\uc744 \ucc28\uc9c0\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc5d0\uc11c\ub294 \uc554 \uc9c4\ub2e8\uc774 \ud06c\uac8c \uc99d\uac00\ud558\uace0 \uc788\uc73c\uba70, \ud2b9\ud788 \ub09c\uc18c\uc554\uacfc \uc720\ubc29\uc554\uc5d0\uc11c PARP \uc5b5\uc81c\uc81c\ub85c \uc790\uc8fc \uce58\ub8cc\ub418\ub294 \uc554\uc774 \uc99d\uac00\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc554\uc758 \uc720\ubcd1\ub960\uc774 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc \uc635\uc158\uc774 \ud544\uc694\ud55c \ud658\uc790 \uc778\uad6c\uac00 \ub354 \ub9ce\uc544\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc758 \uc554 \ubc1c\uc0dd \uac74\uc218\ub294 PARP \uc5b5\uc81c\uc81c\uc5d0 \ub300\ud55c \uc218\uc694\ub97c \uc99d\uac00\uc2dc\ud0ac \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n\uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc740 \uc554 \uc720\ubcd1\ub960 \uc99d\uac00, \uc554 \uad00\ub828 \uc5f0\uad6c \uac1c\ubc1c\uc5d0 \ub300\ud55c \ud22c\uc790 \uc99d\uac00, \ud601\uc2e0\uc801\uc774\uace0 \ud45c\uc801\ud654\ub41c \uce58\ub8cc \uc635\uc158 \uc99d\uac00, \uae30\uc220 \ubc1c\uc804\uacfc \uac19\uc740 \uc694\uc778\uc5d0 \uc758\ud574 \uc8fc\ub3c4\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubcf8\uc774 \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 \ub300\ubd80\ubd84\uc744 \ucc28\uc9c0\ud558\uace0 \uc788\ub294 \uc774\uc720\ub294 \uc77c\ubcf8 \ub0b4 \uc554 \uc720\ubcd1\ub960\uc758 \uc99d\uac00\uac00 PARP \uc5b5\uc81c\uc81c\uc758 \uc911\uc694\ud55c \ub3d9\uc778\uc774\uba70, \uc774\ub7ec\ud55c \uce58\ub8cc\ubc95\uc740 \uae30\uc874 \ud654\ud559 \uc694\ubc95\ubcf4\ub2e4 \ub354 \ud6a8\uacfc\uc801\uc774\uace0 \ub3c5\uc131\uc774 \uc801\uc740 \ud45c\uc801 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uacf5\ud558\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<br \/>\n\uc77c\ubcf8\uc5d0\uc11c \uc720\ubc29\uc554\uc740 \uc804\uccb4 \uc554 \uc911 \uac00\uc7a5 \ube48\ubc88\ud558\uac8c \uc9c4\ub2e8\ub418\ub294 \uc554\uc774\uba70 \uc5ec\uc131\uc5d0\uac8c \uac00\uc7a5 \ud754\ud55c \uc554\uc785\ub2c8\ub2e4. \uc77c\ubcf8 \uc720\ubc29\uc554 \ud658\uc790\uc758 90% \uc774\uc0c1\uc774 \uc870\uae30\uc5d0 \uc9c4\ub2e8\ub429\ub2c8\ub2e4. 2022\ub144\uc5d0\ub294 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \uc57d 230\ub9cc \uac74\uc758 \uc720\ubc29\uc554\uc774 \uc0c8\ub85c \ubc1c\uc0dd\ud588\uc73c\uba70, \uc774\ub85c \uc778\ud574 \uc57d 70\ub9cc \uba85\uc774 \uc0ac\ub9dd\ud588\uc2b5\ub2c8\ub2e4.  \uc804\ub9bd\uc120\uc554\uc740 \ub0a8\uc131\uc5d0\uac8c \ub450 \ubc88\uc9f8\ub85c \ud754\ud558\uac8c \uc9c4\ub2e8\ub418\ub294 \uc554\uc73c\ub85c, \uc804 \uc138\uacc4\uc801\uc73c\ub85c \ub0a8\uc131\uc758 \uc554 \uad00\ub828 \uc0ac\ub9dd \uc6d0\uc778 \uc911 5\uc704\ub97c \ucc28\uc9c0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubcf8\uc5d0\uc11c\ub294 2022\ub144\uc5d0 96,400\uba85\uc758 \uc2e0\uaddc \ud658\uc790\uac00 \ubc1c\uc0dd\ud558\uace0 13,300\uba85\uc774 \uc0ac\ub9dd\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \uc774\ucc98\ub7fc \uc554 \ubc1c\ubcd1 \uac74\uc218\uac00 \uc99d\uac00\ud568\uc5d0 \ub530\ub77c PARP \uc5b5\uc81c\uc81c\uc5d0 \ub300\ud55c \uc218\uc694\uac00 \uc99d\uac00\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\ub610\ud55c \uc774 \uc9c0\uc5ed\uc758 \uc8fc\uc694 \uc5c5\uccb4, \uc5f0\uad6c \uac1c\ubc1c \ubc0f \uc784\uc0c1 \uc2dc\ud5d8\uc758 \uc99d\uac00\uac00 \uc774 PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc758 \uc131\uc7a5\uc744 \uc8fc\ub3c4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, 2023\ub144 8\uc6d4, \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74\uc640 \uba38\ud06c\ub294 \ub9b0\ud30c\uc790(\uc62c\ub77c\ud30c\ub9bd)\uac00 \uc544\ube44\ub77c\ud14c\ub860 \ubc0f \ud504\ub808\ub4dc\ub2c8\uc194\ub860\uacfc \ud568\uaed8 BRCA \ubcc0\uc774(BRCAm) \uc804\uc774\uc131 \uac70\uc138 \uc800\ud56d\uc131 \uc804\ub9bd\uc120\uc554(mCRPC) \uc131\uc778 \ud658\uc790\uc758 \uce58\ub8cc\uc81c\ub85c \uc77c\ubcf8\uc5d0\uc11c \uc2b9\uc778\uc744 \ubc1b\uc558\ub2e4\uace0 \ubc1c\ud45c\ud588\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc704\uc758 \uc694\uc778\uc73c\ub85c \uc778\ud574 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc740 \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc5d0\uc11c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \uc9c0\uc5ed\uc73c\ub85c \uc785\uc9c0\ub97c \uacf5\uace0\ud788 \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc8fc\uc694 \uac1c\ubc1c<br \/>\n2024\ub144 7\uc6d4, \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74\ub294 \uc885\uc591 BRCA \ubcc0\uc774\uac00 \uc5c6\ub294 \uc9c4\ud589\uc131 \uace0\ub4f1\uae09 \uc0c1\ud53c\uc131 \ub09c\uc18c\uc554\uc744 \uc0c8\ub85c \uc9c4\ub2e8\ubc1b\uc740 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ub9b0\ud30c\uc790(\uc62c\ub77c\ud30c\ub9bd)\uc640 \uc784\ud540\uc9c0(\ub354\ubc1c\ub8e8\ub9d9)\ub97c \ud654\ud559\uc694\ubc95 \ubc0f \ubca0\ubc14\uc2dc\uc8fc\ub9d9\uacfc \ubcd1\uc6a9\ud558\ub294 DUO-O 3\uc0c1 \uc784\uc0c1\uc2dc\ud5d8\uc744 \ubc1c\ud45c\ud588\uc2b5\ub2c8\ub2e4.<br \/>\n2023\ub144 6\uc6d4, \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74\uc640 \uba38\ud06c\ub294 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc774 \ub9b0\ud30c\uc790(\uc62c\ub77c\ud30c\ub9bd)\ub97c \uc544\ube44\ub77c\ud14c\ub860 \ubc0f \ud504\ub808\ub4dc\ub2c8\uc190 \ub610\ub294 \ud504\ub808\ub4dc\ub2c8\uc194\ub860\uacfc \ubcd1\uc6a9\ud558\uc5ec \ud574\ub85c\uc6b4 \ub610\ub294 \ud574\ub85c\uc6b4 \uac83\uc73c\ub85c \uc758\uc2ec\ub418\ub294 BRCA \ubcc0\uc774(BRCAm) \uc804\uc774\uc131 \uac70\uc138 \uc800\ud56d\uc131 \uc804\ub9bd\uc120\uc554(mCRPC) \uc131\uc778 \ud658\uc790\uc758 \uce58\ub8cc\uc81c\ub85c \uc2b9\uc778\ud588\ub2e4\uace0 \ubc1c\ud45c\ud588\uc2b5\ub2c8\ub2e4.<br \/>\n\ubcf4\uace0\uc11c\ub97c \uad6c\ub9e4\ud558\ub294 \uc774\uc720\ub294 \ubb34\uc5c7\uc778\uac00\uc694?<br \/>\n\uc81c\ud488 \uc720\ud615, \uc751\uc6a9 \ubd84\uc57c, \uc720\ud1b5 \ucc44\ub110 \ubc0f \uc9c0\uc5ed\uc5d0 \ub530\ub77c \uae00\ub85c\ubc8c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5 \uc138\ubd84\ud654\ub97c \uc2dc\uac01\ud654\ud558\uace0 \uc8fc\uc694 \uc0c1\uc5c5 \uc790\uc0b0 \ubc0f \ud50c\ub808\uc774\uc5b4\ub97c \uc774\ud574\ud569\ub2c8\ub2e4.<br \/>\n\ub3d9\ud5a5\uacfc \uacf5\ub3d9 \uac1c\ubc1c\uc744 \ubd84\uc11d\ud558\uc5ec \uc0c1\uc5c5\uc801 \uae30\ud68c\ub97c \ud30c\uc545\ud569\ub2c8\ub2e4.<br \/>\n\ubaa8\ub4e0 \uc138\uadf8\uba3c\ud2b8\uac00 \ud3ec\ud568 \ub41c PARP \uc5b5\uc81c\uc81c \uc2dc\uc7a5\uc758 \uc218\ub9ce\uc740 \ub370\uc774\ud130 \ud3ec\uc778\ud2b8\uac00 \ud3ec\ud568 \ub41c Excel \ub370\uc774\ud130 \uc2dc\ud2b8.<br \/>\nPDF \ubcf4\uace0\uc11c\ub294 \ucca0\uc800\ud55c \uc815\uc131\uc801 \uc778\ud130\ubdf0\uc640 \uc2ec\uce35 \uc5f0\uad6c\ub97c \uac70\uce5c \uc885\ud569\uc801\uc778 \ubd84\uc11d\uc73c\ub85c \uad6c\uc131\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\ubaa8\ub4e0 \uc8fc\uc694 \uc5c5\uccb4\uc758 \uc8fc\uc694 \uc81c\ud488\uc73c\ub85c \uad6c\uc131\ub41c \uc81c\ud488 \ub9e4\ud551\uc774 \uc5d1\uc140\ub85c \uc81c\uacf5\ub429\ub2c8\ub2e4.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-19111","post","type-post","status-publish","format-standard","hentry","category-industry-research-report"],"_links":{"self":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/posts\/19111"}],"collection":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/comments?post=19111"}],"version-history":[{"count":0,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/posts\/19111\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/media?parent=19111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/categories?post=19111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/tags?post=19111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}