{"id":41538,"date":"2026-02-13T16:18:39","date_gmt":"2026-02-13T16:18:39","guid":{"rendered":"https:\/\/www.globalresearch.co.kr\/insight\/dna-repair-drugs-mordor\/"},"modified":"2026-10-02T23:35:59","modified_gmt":"2026-10-02T14:35:59","slug":"dna-repair-drugs-mordor","status":"publish","type":"post","link":"https:\/\/www.globalresearch.co.kr\/insight\/dna-repair-drugs-mordor\/","title":{"rendered":"\uc138\uacc4\uc758 DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5 \uaddc\ubaa8 \ubc0f \uc810\uc720\uc728 \ubd84\uc11d &#8211; \uc131\uc7a5 \ub3d9\ud5a5 \ubc0f \uc804\ub9dd (2026-2031\ub144)"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/www.globalresearch.co.kr\/insight\/wp-content\/uploads\/2026\/02\/dna-repair-drugs-1748881043110-major-players.webp\" alt=\"Chart\" class=\"aligncenter size-full\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.globalresearch.co.kr\/insight\/wp-content\/uploads\/2026\/02\/dna-repair-drugs-size-image-1767807995246.webp\" alt=\"Chart\" class=\"aligncenter size-full\" \/><\/p>\n<p class=\"toc-level-1 toc-content-heading\" id=\"toc-content-heading-0\">1. \uc11c\ub860<\/p>\n<ul>\n<li class=\"toc-level-2\">1.1 \uc5f0\uad6c \uac00\uc815 \ubc0f \uc2dc\uc7a5 \uc815\uc758<\/li>\n<li class=\"toc-level-2\">1.2 \uc5f0\uad6c \ubc94\uc704<\/li>\n<\/ul>\n<p class=\"toc-level-1 toc-content-heading\" id=\"toc-content-heading-1\">2. \uc5f0\uad6c \ubc29\ubc95\ub860<\/p>\n<p class=\"toc-level-1 toc-content-heading\" id=\"toc-content-heading-2\">3. \uc694\uc57d<\/p>\n<p class=\"toc-level-1 toc-content-heading\" id=\"toc-content-heading-3\">4. \uc2dc\uc7a5 \ud658\uacbd<\/p>\n<ul>\n<li class=\"toc-level-2\">4.1 \uc2dc\uc7a5 \uac1c\uc694<\/li>\n<li class=\"toc-level-2\">4.2 \uc2dc\uc7a5 \ub3d9\uc778\n<ul>\n<li class=\"toc-level-3\">4.2.1 HR \uacb0\ud54d \uace0\ud615\uc554 \ubc1c\ubcd1\ub960 \uc99d\uac00<\/li>\n<li class=\"toc-level-3\">4.2.2 PARP \uc5b5\uc81c\uc81c\uc758 \ucd08\uae30 \uce58\ub8cc \ubc0f \uc720\uc9c0 \uc694\ubc95\uc73c\ub85c\uc758 \uc801\uc751\uc99d \ud655\ub300<\/li>\n<li class=\"toc-level-3\">4.2.3 \ud569\uc131 \uce58\uc0ac \ubcd1\uc6a9 \uc694\ubc95 \ucc44\ud0dd<\/li>\n<li class=\"toc-level-3\">4.2.4 \uc885\uc591\ud559 \ucc98\ubc29\uc9d1\uc5d0\uc11c \uacbd\uad6c\uc6a9 \ud56d\uc554\uc81c\ub85c\uc758 \uc804\ud658<\/li>\n<li class=\"toc-level-3\">4.2.5 \uc2dc\uc7a5 \ucd9c\uc2dc \uae30\uac04\uc744 \ub2e8\ucd95\ud558\ub294 \uc2e0\uc18d\ud55c \uaddc\uc81c \uacbd\ub85c<\/li>\n<li class=\"toc-level-3\">4.2.6 \ub3d9\ubc18 \uc9c4\ub2e8 \ucc44\ud0dd\uc744 \ucd09\uc9c4\ud558\ub294 \uacf5\uacf5 \uc815\ubc00 \uc885\uc591\ud559 \uc774\ub2c8\uc154\ud2f0\ube0c<\/li>\n<\/ul>\n<\/li>\n<li class=\"toc-level-2\">4.3 \uc2dc\uc7a5 \uc81c\uc57d\n<ul>\n<li class=\"toc-level-3\">4.3.1 HRD \/ BRCA \uac80\uc0ac\uc758 \ub192\uc740 \ube44\uc6a9\uc73c\ub85c \uc778\ud55c \uc801\uaca9 \ud658\uc790 \ud480 \uc81c\ud55c<\/li>\n<li class=\"toc-level-3\">4.3.2 \uc548\uc804\uc131 \uc2e0\ud638 &#8211; \uace8\uc218 \uc5b5\uc81c \ubc0f MDS\/AML &#8211; \uce58\ub8cc \uae30\uac04 \uc81c\ud55c<\/li>\n<li class=\"toc-level-3\">4.3.3 \ud45c\uc900 \ud654\ud559\uc694\ubc95 \ub300\ube44 \uc804\uccb4 \uc0dd\uc874 \uc774\uc810\uc5d0 \ub300\ud55c \uc9c0\ubd88\uc790\uc758 \uc2ec\uc0ac \uac15\ud654<\/li>\n<li class=\"toc-level-3\">4.3.4 1\uc138\ub300 PARP \uc5b5\uc81c\uc81c\uc758 2028-30\ub144 \ud2b9\ud5c8 \ub9cc\ub8cc\ub85c \uc778\ud55c \uc218\uc775 \uac00\uc2dc\uc131 \uc800\ud558<\/li>\n<\/ul>\n<\/li>\n<li class=\"toc-level-2\">4.4 \uacf5\uae09\ub9dd \ubd84\uc11d<\/li>\n<li class=\"toc-level-2\">4.5 \uaddc\uc81c \uc804\ub9dd<\/li>\n<li class=\"toc-level-2\">4.6 \ud3ec\ud130\uc758 5\uac00\uc9c0 \uacbd\uc7c1 \uc694\uc778 \ubd84\uc11d\n<ul>\n<li class=\"toc-level-3\">4.6.1 \uc2e0\uaddc \uc9c4\uc785\uc790\uc758 \uc704\ud611<\/li>\n<li class=\"toc-level-3\">4.6.2 \uad6c\ub9e4\uc790\uc758 \uad50\uc12d\ub825<\/li>\n<li class=\"toc-level-3\">4.6.3 \uacf5\uae09\uc5c5\uccb4\uc758 \uad50\uc12d\ub825<\/li>\n<li class=\"toc-level-3\">4.6.4 \ub300\uccb4\uc7ac\uc758 \uc704\ud611<\/li>\n<li class=\"toc-level-3\">4.6.5 \uacbd\uc7c1 \uac15\ub3c4<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"toc-level-1 toc-content-heading\" id=\"toc-content-heading-4\">5. \uc2dc\uc7a5 \uaddc\ubaa8 \ubc0f \uc131\uc7a5 \uc608\uce21 (\uac00\uce58, USD)<\/p>\n<ul>\n<li class=\"toc-level-2\">5.1 \uc57d\ubb3c \uc720\ud615\ubcc4\n<ul>\n<li class=\"toc-level-3\">5.1.1 PARP \uc5b5\uc81c\uc81c<\/li>\n<li class=\"toc-level-3\">5.1.2 ATM \ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc81c<\/li>\n<li class=\"toc-level-3\">5.1.3 ATR \uc5b5\uc81c\uc81c<\/li>\n<li class=\"toc-level-3\">5.1.4 DNA-PK \uc5b5\uc81c\uc81c<\/li>\n<li class=\"toc-level-3\">5.1.5 \uae30\ud0c0 \uc57d\ubb3c \uc720\ud615<\/li>\n<\/ul>\n<\/li>\n<li class=\"toc-level-2\">5.2 \uc801\uc751\uc99d\ubcc4\n<ul>\n<li class=\"toc-level-3\">5.2.1 \ub09c\uc18c\uc554<\/li>\n<li class=\"toc-level-3\">5.2.2 \uc720\ubc29\uc554<\/li>\n<li class=\"toc-level-3\">5.2.3 \uc804\ub9bd\uc120\uc554<\/li>\n<li class=\"toc-level-3\">5.2.4 \ucdcc\uc7a5\uc554<\/li>\n<li class=\"toc-level-3\">5.2.5 \uad50\ubaa8\uc138\ud3ec\uc885 &amp; \uc911\ucd94\uc2e0\uacbd\uacc4 \uc885\uc591<\/li>\n<li class=\"toc-level-3\">5.2.6 \uae30\ud0c0 \uc801\uc751\uc99d<\/li>\n<\/ul>\n<\/li>\n<li class=\"toc-level-2\">5.3 \uce58\ub8cc \ub77c\uc778\ubcc4\n<ul>\n<li class=\"toc-level-3\">5.3.1 1\ucc28 \uc720\uc9c0\uc694\ubc95<\/li>\n<li class=\"toc-level-3\">5.3.2 2\ucc28\/\ud6c4\uc18d \uce58\ub8cc<\/li>\n<\/ul>\n<\/li>\n<li class=\"toc-level-2\">5.4 \uc720\ud1b5 \ucc44\ub110\ubcc4\n<ul>\n<li class=\"toc-level-3\">5.4.1 \ubcd1\uc6d0 \uc57d\uad6d<\/li>\n<li class=\"toc-level-3\">5.4.2 \uc804\ubb38 &amp; \uc18c\ub9e4 \uc57d\uad6d<\/li>\n<li class=\"toc-level-3\">5.4.3 \uc628\ub77c\uc778 \uc57d\uad6d<\/li>\n<\/ul>\n<\/li>\n<li class=\"toc-level-2\">5.5 \uc9c0\uc5ed\ubcc4 (\uac00\uce58)\n<ul>\n<li class=\"toc-level-3\">5.5.1 \ubd81\ubbf8<\/li>\n<li class=\"toc-level-4\">5.5.1.1 \ubbf8\uad6d<\/li>\n<li class=\"toc-level-4\">5.5.1.2 \uce90\ub098\ub2e4<\/li>\n<li class=\"toc-level-4\">5.5.1.3 \uba55\uc2dc\ucf54<\/li>\n<li class=\"toc-level-3\">5.5.2 \uc720\ub7fd<\/li>\n<li class=\"toc-level-4\">5.5.2.1 \ub3c5\uc77c<\/li>\n<li class=\"toc-level-4\">5.5.2.2 \uc601\uad6d<\/li>\n<li class=\"toc-level-4\">5.5.2.3 \ud504\ub791\uc2a4<\/li>\n<li class=\"toc-level-4\">5.5.2.4 \uc774\ud0c8\ub9ac\uc544<\/li>\n<li class=\"toc-level-4\">5.5.2.5 \uc2a4\ud398\uc778<\/li>\n<li class=\"toc-level-4\">5.5.2.6 \uae30\ud0c0 \uc720\ub7fd<\/li>\n<li class=\"toc-level-3\">5.5.3 \uc544\uc2dc\uc544-\ud0dc\ud3c9\uc591<\/li>\n<li class=\"toc-level-4\">5.5.3.1 \uc911\uad6d<\/li>\n<li class=\"toc-level-4\">5.5.3.2 \uc778\ub3c4<\/li>\n<li class=\"toc-level-4\">5.5.3.3 \uc77c\ubcf8<\/li>\n<li class=\"toc-level-4\">5.5.3.4 \ud638\uc8fc<\/li>\n<li class=\"toc-level-4\">5.5.3.5 \ub300\ud55c\ubbfc\uad6d<\/li>\n<li class=\"toc-level-4\">5.5.3.6 \uae30\ud0c0 \uc544\uc2dc\uc544-\ud0dc\ud3c9\uc591<\/li>\n<li class=\"toc-level-3\">5.5.4 \uc911\ub3d9 &amp; \uc544\ud504\ub9ac\uce74<\/li>\n<li class=\"toc-level-4\">5.5.4.1 GCC<\/li>\n<li class=\"toc-level-4\">5.5.4.2 \ub0a8\uc544\ud504\ub9ac\uce74<\/li>\n<li class=\"toc-level-4\">5.5.4.3 \uae30\ud0c0 \uc911\ub3d9 &amp; \uc544\ud504\ub9ac\uce74<\/li>\n<li class=\"toc-level-3\">5.5.5 \ub0a8\uc544\uba54\ub9ac\uce74<\/li>\n<li class=\"toc-level-4\">5.5.5.1 \ube0c\ub77c\uc9c8<\/li>\n<li class=\"toc-level-4\">5.5.5.2 \uc544\ub974\ud5e8\ud2f0\ub098<\/li>\n<li class=\"toc-level-4\">5.5.5.3 \uae30\ud0c0 \ub0a8\uc544\uba54\ub9ac\uce74<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"toc-level-1 toc-content-heading\" id=\"toc-content-heading-5\">6. \uacbd\uc7c1 \ud658\uacbd<\/p>\n<ul>\n<li class=\"toc-level-2\">6.1 \uc2dc\uc7a5 \uc9d1\uc911\ub3c4<\/li>\n<li class=\"toc-level-2\">6.2 \uacbd\uc7c1 \ubca4\uce58\ub9c8\ud0b9<\/li>\n<li class=\"toc-level-2\">6.3 \uc2dc\uc7a5 \uc810\uc720\uc728 \ubd84\uc11d<\/li>\n<li class=\"toc-level-2\">6.4 \uae30\uc5c5 \ud504\ub85c\ud544 (\uae00\ub85c\ubc8c \uac1c\uc694, \uc2dc\uc7a5 \uac1c\uc694, \ud575\uc2ec \ubd80\ubb38, \uc7ac\ubb34 \uc815\ubcf4(\uac00\ub2a5\ud55c \uacbd\uc6b0), \uc804\ub7b5 \uc815\ubcf4, \uc8fc\uc694 \uae30\uc5c5\uc758 \uc2dc\uc7a5 \uc21c\uc704\/\uc810\uc720\uc728, \uc81c\ud488 \ubc0f \uc11c\ube44\uc2a4, \ucd5c\uadfc \uac1c\ubc1c \ud3ec\ud568)\n<ul>\n<li class=\"toc-level-3\">6.4.1 AbbVie Inc.<\/li>\n<li class=\"toc-level-3\">6.4.2 Allarity Therapeutics Inc.<\/li>\n<li class=\"toc-level-3\">6.4.3 Antengene Corporation Limited<\/li>\n<li class=\"toc-level-3\">6.4.4 Artios Pharma Ltd.<\/li>\n<li class=\"toc-level-3\">6.4.5 AstraZeneca PLC<\/li>\n<li class=\"toc-level-3\">6.4.6 Breakpoint Therapeutics GmbH<\/li>\n<li class=\"toc-level-3\">6.4.7 FoRx Therapeutics AG<\/li>\n<li class=\"toc-level-3\">6.4.8 GlaxoSmithKline PLC<\/li>\n<li class=\"toc-level-3\">6.4.9 Ideaya Biosciences<\/li>\n<li class=\"toc-level-3\">6.4.10 Johnson &amp; Johnson (Janssen)<\/li>\n<li class=\"toc-level-3\">6.4.11 Merck KGaA (EMD Serono)<\/li>\n<li class=\"toc-level-3\">6.4.12 Novartis AG<\/li>\n<li class=\"toc-level-3\">6.4.13 Pfizer Inc.<\/li>\n<li class=\"toc-level-3\">6.4.14 Rakovina Therapeutics Inc.<\/li>\n<li class=\"toc-level-3\">6.4.15 Repare Therapeutics Inc.<\/li>\n<li class=\"toc-level-3\">6.4.16 Tolmar, Inc<\/li>\n<li class=\"toc-level-3\">6.4.17 Valerio Therapeutics<\/li>\n<li class=\"toc-level-3\">6.4.18 Zai Lab Ltd.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"toc-level-1 toc-content-heading\" id=\"toc-content-heading-6\">7. \uc2dc\uc7a5 \uae30\ud68c \ubc0f \ubbf8\ub798 \uc804\ub9dd<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5 \uac1c\uc694 (2026-2031\ub144)<\/p>\n<p># 1. \uc2dc\uc7a5 \uaddc\ubaa8 \ubc0f \uc131\uc7a5 \uc804\ub9dd<\/p>\n<p>DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5\uc740 2025\ub144 89\uc5b5 3\ucc9c\ub9cc \ub2ec\ub7ec\uc5d0\uc11c 2026\ub144 100\uc5b5 9\ucc9c\ub9cc \ub2ec\ub7ec\ub85c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uba70, 2026\ub144\ubd80\ud130 2031\ub144\uae4c\uc9c0 \uc5f0\ud3c9\uade0 \uc131\uc7a5\ub960(CAGR) 12.94%\ub97c \uae30\ub85d\ud558\uba70 2031\ub144\uc5d0\ub294 185\uc5b5 3\ucc9c\ub9cc \ub2ec\ub7ec\uc5d0 \uc774\ub97c \uac83\uc73c\ub85c \uc804\ub9dd\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc131\uc7a5\uc740 \ud3f4\ub9ac(ADP-\ub9ac\ubcf4\uc2a4) \uc911\ud569\ud6a8\uc18c(PARP) \uc5b5\uc81c\uc81c\uc758 \uc784\uc0c1\uc801 \uc131\uacf5, \ub3d9\uc885 \uc7ac\uc870\ud569 \uacb0\ud54d(HRD) \uac80\uc0ac\uc758 \uae09\uc18d\ud55c \ud655\ub300, \uacbd\uad6c\uc6a9 \ud56d\uc554\uc81c\ub85c\uc758 \uc804\ud658 \ub4f1\uc5d0 \ud798\uc785\uc5b4 \ub450 \uc790\ub9bf\uc218 \uc131\uc7a5\uc744 \uc9c0\uc18d\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ud30c\uc774\ud504\ub77c\uc778 \ub2e4\uac01\ud654 \uce21\uba74\uc5d0\uc11c\ub294 \uc544\ud0c0\uc2dc\uc544 \ud154\ub791\uae30\uc5d1\ud0c0\uc2dc\uc544 \ubcc0\uc774(ATM), \uc544\ud0c0\uc2dc\uc544 \ud154\ub791\uae30\uc5d1\ud0c0\uc2dc\uc544 \ubc0f Rad3 \uad00\ub828(ATR), DNA-PK \uc5b5\uc81c\uc81c \ub4f1\uc73c\ub85c \uacbd\uc7c1 \uad6c\ub3c4\uac00 \ud655\ub300\ub418\uace0 \uc788\uc73c\uba70, \uc2e0\uc18d\ud55c \uaddc\uc81c \uc2b9\uc778 \uc808\ucc28\ub294 \uc57d\ubb3c \ucd9c\uc2dc \uae30\uac04\uc744 \uc57d 2.5\ub144 \ub2e8\ucd95\uc2dc\ud0a4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c, 1\ucc28 \uc720\uc9c0 \uc694\ubc95\uc774 \uc5ec\ub7ec \uc554\uc885\uc5d0\uc11c \ud6c4\uae30 \uad6c\uc81c \uc694\ubc95\uc744 \ub300\uccb4\ud558\uba74\uc11c \ud3c9\uade0 \uce58\ub8cc \uae30\uac04\uc774 \uae38\uc5b4\uc9c0\uace0 \ud658\uc790\ub2f9 \uc218\uc775\uc774 \uc99d\uac00\ud558\ub294 \ucd94\uc138\uc785\ub2c8\ub2e4. \uc9c0\uc5ed\ubcc4\ub85c\ub294 \ubd81\ubbf8\uac00 \uc5ec\uc804\ud788 \uc8fc\uc694 \uc218\uc775 \uae30\uc5ec\uc790\uc774\uc9c0\ub9cc, \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed\uc740 \ucc28\uc138\ub300 \uc5fc\uae30\uc11c\uc5f4 \ubd84\uc11d(NGS) \ubc0f \ub3d9\ubc18 \uc9c4\ub2e8 \uc811\uadfc\uc131\uc744 \ud655\ub300\ud558\ub294 \uc815\ubd80 \uc9c0\uc6d0 \uc815\ubc00 \uc885\uc591\ud559 \ud504\ub85c\uadf8\ub7a8\uc5d0 \ud798\uc785\uc5b4 \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc8fc\uc694 \uc2dc\uc7a5 \uc9c0\ud45c (2020-2031\ub144)<br \/>\n*   \uc5f0\uad6c \uae30\uac04: 2020\ub144 \u2013 2031\ub144<br \/>\n*   2026\ub144 \uc2dc\uc7a5 \uaddc\ubaa8: 100\uc5b5 9\ucc9c\ub9cc \ub2ec\ub7ec<br \/>\n*   2031\ub144 \uc2dc\uc7a5 \uaddc\ubaa8: 185\uc5b5 3\ucc9c\ub9cc \ub2ec\ub7ec<br \/>\n*   \uc131\uc7a5\ub960 (2026\ub144 \u2013 2031\ub144): \uc5f0\ud3c9\uade0 12.94%<br \/>\n*   \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud558\ub294 \uc2dc\uc7a5: \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591<br \/>\n*   \uac00\uc7a5 \ud070 \uc2dc\uc7a5: \ubd81\ubbf8<br \/>\n*   \uc2dc\uc7a5 \uc9d1\uc911\ub3c4: \uc911\uac04<\/p>\n<p># 2. \uc8fc\uc694 \ubcf4\uace0\uc11c \uc694\uc57d<\/p>\n<p>*   \uc57d\ubb3c \uc720\ud615\ubcc4: PARP \uc5b5\uc81c\uc81c\uac00 2025\ub144 DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 49.02%\ub97c \ucc28\uc9c0\ud588\uc73c\uba70, ATM \ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc81c\ub294 2031\ub144\uae4c\uc9c0 18.92%\uc758 \uac00\uc7a5 \ube60\ub978 CAGR\uc744 \uae30\ub85d\ud560 \uac83\uc73c\ub85c \uc804\ub9dd\ub429\ub2c8\ub2e4.<br \/>\n*   \uc801\uc751\uc99d\ubcc4: \ub09c\uc18c\uc554\uc774 2025\ub144 DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5 \uaddc\ubaa8\uc758 38.72%\ub97c \ucc28\uc9c0\ud588\uc73c\uba70, \uc804\ub9bd\uc120\uc554\uc740 2031\ub144\uae4c\uc9c0 17.86%\uc758 CAGR\ub85c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n*   \uce58\ub8cc \ub77c\uc778\ubcc4: 2\ucc28\/\ud6c4\uc18d \uce58\ub8cc\uac00 2025\ub144 \uc810\uc720\uc728\uc758 77.65%\ub85c \uac00\uc7a5 \ud070 \ube44\uc911\uc744 \ucc28\uc9c0\ud588\uc9c0\ub9cc, 1\ucc28 \uc720\uc9c0 \uc694\ubc95\uc740 \uc608\uce21 \uae30\uac04 \ub3d9\uc548 17.24%\uc758 CAGR\ub85c \uac00\uc7a5 \uc5ed\ub3d9\uc801\uc778 \uc131\uc7a5\uc138\ub97c \ubcf4\uc77c \uac83\uc73c\ub85c \uc804\ub9dd\ub429\ub2c8\ub2e4.<br \/>\n*   \uc720\ud1b5 \ucc44\ub110\ubcc4: \ubcd1\uc6d0 \uc57d\uad6d\uc774 2025\ub144 \uc218\uc775 \uc810\uc720\uc728\uc758 55.18%\ub97c \ucc28\uc9c0\ud588\uc73c\uba70, \uc804\ubb38 \ubc0f \uc18c\ub9e4 \uc57d\uad6d\uc740 2031\ub144\uae4c\uc9c0 15.12%\uc758 \uac00\uc7a5 \ube60\ub978 CAGR\ub85c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<br \/>\n*   \uc9c0\uc5ed\ubcc4: \ubd81\ubbf8\uac00 2025\ub144 DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5 \uaddc\ubaa8\uc758 47.35%\ub97c \ucc28\uc9c0\ud588\uc73c\uba70, \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591\uc740 2031\ub144\uae4c\uc9c0 16.35%\uc758 CAGR\ub85c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc804\ub9dd\ub429\ub2c8\ub2e4.<\/p>\n<p># 3. \uae00\ub85c\ubc8c DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5 \ub3d9\ud5a5 \ubc0f \ud1b5\ucc30\ub825<\/p>\n<p>3.1. \uc2dc\uc7a5 \uc131\uc7a5 \ub3d9\uc778<\/p>\n<p>*   HR \uacb0\ud54d \uace0\ud615 \uc885\uc591\uc758 \ubc1c\uc0dd\ub960 \uc99d\uac00: HRD \uac80\uc0ac\uc758 \ud655\ub300\ub294 DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5\uc758 \uce58\ub8cc \uac00\ub2a5\ud55c \ud658\uc790\uad70\uc744 \ub298\ub9ac\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uace0\ub4f1\uae09 \uc7a5\uc561\uc131 \ub09c\uc18c\uc554\uc758 \uc57d 50%, \uc804\ub9bd\uc120\uc554\uc758 \ucd5c\ub300 25%\uac00 DNA \ubcf5\uad6c \uacb0\ud568\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \ucc28\uc138\ub300 \uc5fc\uae30\uc11c\uc5f4 \ubd84\uc11d(NGS) \ud328\ub110\uc758 \uc77c\uc0c1\uc801\uc778 \uc9c4\ub8cc \ud1b5\ud569\uc740 \uc0c8\ub85c\uc6b4 \ud658\uc790 \ud480\uc744 \ubc1c\uad74\ud558\uace0 \ucc98\ubc29 \uc131\uc7a5\uc744 \uc9c0\uc18d\uc2dc\ud0a4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud2b9\ud788 \uc9c0\ubd88\uc790 \ubcf4\uc7a5\uc774 \uc798 \ub418\uc5b4 \uc788\ub294 \uc9c0\uc5ed\uc5d0\uc11c \uc774\ub7ec\ud55c \uacbd\ud5a5\uc774 \ub450\ub4dc\ub7ec\uc9d1\ub2c8\ub2e4.<br \/>\n*   PARP \uc5b5\uc81c\uc81c\uc758 \uc870\uae30 \ubc0f \uc720\uc9c0 \uc694\ubc95\uc73c\ub85c\uc758 \uc801\uc751\uc99d \ud655\ub300: 1\ucc28 \uc720\uc9c0 \uc694\ubc95\uc73c\ub85c PARP \uc5b5\uc81c\uc81c\ub97c \uc0ac\uc6a9\ud558\uba74 \ud6c4\uae30 \uc694\ubc95 \ub300\ube44 \uce58\ub8cc \uae30\uac04\uc774 10~12\uac1c\uc6d4 \uc5f0\uc7a5\ub429\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, PRIMA \uc784\uc0c1\uc5d0\uc11c \ub2c8\ub77c\ud30c\ub9bd\uc740 HRD \uc591\uc131 \ub09c\uc18c\uc554 \ud658\uc790\uc5d0\uc11c 35%\uc758 5\ub144 \ubb34\uc9c4\ud589 \uc0dd\uc874\uc728(PFS)\uc744 \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc7a5\uae30 \ub178\ucd9c\uc740 \ub204\uc801 \ub9e4\ucd9c\uc744 \ub192\uc774\uace0 \ud574\ub2f9 \uc57d\ubb3c \uacc4\uc5f4\uc758 \uc2dc\uc7a5 \uc9c0\uc704\ub97c \uac15\ud654\ud569\ub2c8\ub2e4.<br \/>\n*   \ud569\uc131 \uce58\uc0ac \ubcd1\uc6a9 \uc694\ubc95\uc758 \ucc44\ud0dd: ATR \ub610\ub294 ATM \uc5b5\uc81c\uc81c\ub97c PARP \uc81c\uc81c\uc640 \ubcd1\uc6a9\ud558\uba74 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\ub97c \ub0b4\uc5b4 \ub0b4\uc131\uc744 \uadf9\ubcf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. Merck\uc758 DDRiver 301 \uc5f0\uad6c\uc5d0\uc11c ATR \uc5b5\uc81c\uc81c \ud22c\ubd80\uc11c\ud301\uacfc \ub2c8\ub77c\ud30c\ub9bd \ubcd1\uc6a9\uc740 \ub2e8\ub3c5 \uc694\ubc95 \ub300\ube44 PFS\ub97c \uc57d 35% \uac1c\uc120\ud558\uc5ec, \uae30\uc874 HRD \uc885\uc591 \uc678\uc5d0\ub3c4 \uc801\uc6a9 \ubc94\uc704\ub97c \ub113\ud614\uc2b5\ub2c8\ub2e4.<br \/>\n*   \uc885\uc591\ud559 \ucc98\ubc29\uc5d0\uc11c \uacbd\uad6c\uc6a9 \ud56d\uc554\uc81c\ub85c\uc758 \uc804\ud658: \uacbd\uad6c \ud22c\uc5ec\ub294 \uc678\ub798 \ud658\uc790 \ubaa8\ub378 \ubc0f \uc804\ubb38 \uc57d\uad6d \ud1b5\ud569\uacfc \uc77c\uce58\ud569\ub2c8\ub2e4. 2024\ub144 2\uc6d4 \ubc1c\ud45c\ub41c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, Medicare Part D\uc758 \uacbd\uad6c\uc6a9 \ud56d\uc554\uc81c \ucc98\ubc29\uc740 2011\ub144 10%\uc5d0\uc11c 2019\ub144 34%\ub85c \uc99d\uac00\ud558\uc5ec, \ubcf5\uc57d \uc21c\uc751\ub3c4\ub97c \ub192\uc774\uace0 \ud310\ub9e4 \uc2dc\uc810 \ube44\uc6a9\uc744 \uc57d 20% \uc808\uac10\ud588\uc2b5\ub2c8\ub2e4.<br \/>\n*   \uc2e0\uc18d\ud55c \uaddc\uc81c \uc2b9\uc778 \uacbd\ub85c\ub97c \ud1b5\ud55c \uc2dc\uc7a5 \ucd9c\uc2dc \uae30\uac04 \ub2e8\ucd95: \ubd81\ubbf8\uc640 \uc720\ub7fd\uc744 \uc911\uc2ec\uc73c\ub85c \uc2e0\uc18d\ud55c \uaddc\uc81c \uc2b9\uc778 \uc808\ucc28\uac00 \ub3c4\uc785\ub418\uc5b4 \uc57d\ubb3c \uac1c\ubc1c \ubc0f \ucd9c\uc2dc \uae30\uac04\uc774 \ub2e8\ucd95\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n*   \uc815\ubd80 \uc9c0\uc6d0 \uc815\ubc00 \uc885\uc591\ud559 \uc774\ub2c8\uc154\ud2f0\ube0c\ub97c \ud1b5\ud55c \ub3d9\ubc18 \uc9c4\ub2e8 \ucc44\ud0dd \uc99d\uac00: \ubd81\ubbf8, \uc720\ub7fd \ubc0f \uc544\uc2dc\uc544 \uc120\uc9c4 \uc2dc\uc7a5\uc5d0\uc11c \uc815\ubd80 \uc9c0\uc6d0 \uc815\ubc00 \uc885\uc591\ud559 \uc774\ub2c8\uc154\ud2f0\ube0c\ub294 \ub3d9\ubc18 \uc9c4\ub2e8(Companion-Dx) \ucc44\ud0dd\uc744 \ucd09\uc9c4\ud558\uc5ec, NGS \ubc0f \ub3d9\ubc18 \uc9c4\ub2e8 \uc811\uadfc\uc131\uc744 \ud655\ub300\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>3.2. \uc2dc\uc7a5 \uc131\uc7a5 \uc800\ud574 \uc694\uc778<\/p>\n<p>*   HRD\/BRCA \uac80\uc0ac\uc758 \ub192\uc740 \ube44\uc6a9\uc73c\ub85c \uc778\ud55c \uc801\uaca9 \ud658\uc790 \ud480 \uc81c\ud55c: \uc885\ud569 \uc720\uc804\uccb4 \ud504\ub85c\ud30c\uc77c\ub9c1 \ube44\uc6a9\uc740 \ud658\uc790\ub2f9 3,500~5,800\ub2ec\ub7ec\uc5d0 \ub2ec\ud558\uc5ec, \ubbf8\uad6d \ub0b4 \uac00\uc774\ub4dc\ub77c\uc778 \uc801\uaca9 \ub09c\uc18c\uc554 \ud658\uc790\uc758 47%\ub9cc\uc774 \uac80\uc0ac\ub97c \ubc1b\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc800\uc18c\ub4dd \ubc0f \uc911\uac04 \uc18c\ub4dd \uc9c0\uc5ed\uc5d0\uc11c\ub294 \uc774\ub7ec\ud55c \ube44\uc6a9 \uaca9\ucc28\uac00 \ub354\uc6b1 \ucee4\uc11c, \ud45c\uc801 \uce58\ub8cc\uc5d0 \uc811\uadfc\ud560 \uc218 \uc788\ub294 \uc2e4\uc81c \ud658\uc790 \uc218\uac00 \uc904\uc5b4\ub4e4\uace0 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n*   \uace8\uc218 \uc5b5\uc81c \ubc0f MDS\/AML \uc548\uc804\uc131 \uc2e0\ud638\ub85c \uc778\ud55c \uce58\ub8cc \uae30\uac04 \uc81c\ud55c: PARP \uc5b5\uc81c\uc81c\uc758 \uc7a5\uae30 \ub178\ucd9c\uc740 \uace8\uc218\uc774\ud615\uc131 \uc99d\ud6c4\uad70(MDS) \ubc0f \uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1(AML) \ubc1c\uc0dd\ub960\uc744 \ub192\uc5ec, \uaddc\uc81c \ub2f9\uad6d\uc774 \ud2b9\uc815 \ud6c4\uae30 \uc801\uc751\uc99d\uc744 \ucca0\ud68c\ud558\uac8c \ub9cc\ub4e4\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\uc5d0 \ub530\ub77c \uc784\uc0c1\uc758\ub4e4\uc740 \uc9c0\uc18d\uc801\uc778 \ud22c\uc5ec \ub300\uc2e0 \uae30\uac04 \uc81c\ud55c \uc694\ubc95\uc744 \ucc44\ud0dd\ud558\uace0 \uc788\uc5b4, \ud658\uc790\ub2f9 \ucd1d \uce58\ub8cc \uae30\uac04\uc774 \uc81c\ud55c\ub429\ub2c8\ub2e4.<br \/>\n*   \ud45c\uc900 \ud654\ud559 \uc694\ubc95 \ub300\ube44 \uc804\uccb4 \uc0dd\uc874 \uc774\uc810\uc5d0 \ub300\ud55c \uc9c0\ubd88\uc790\uc758 \uc2ec\uc0ac \uac15\ud654: \ud2b9\ud788 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc2e0\ud765 \uc2dc\uc7a5, \uc0ac\ud558\ub77c \uc774\ub0a8 \uc544\ud504\ub9ac\uce74, \ub0a8\ubbf8 \uc77c\ubd80 \uc9c0\uc5ed\uc5d0\uc11c \uc9c0\ubd88\uc790\ub4e4\uc740 DNA \ubcf5\uad6c \uc57d\ubb3c\uc758 \uc804\uccb4 \uc0dd\uc874 \uc774\uc810\uc5d0 \ub300\ud574 \ud45c\uc900 \ud654\ud559 \uc694\ubc95\uacfc \ube44\uad50\ud558\uc5ec \ub354\uc6b1 \uc5c4\uaca9\ud558\uac8c \uc2ec\uc0ac\ud558\uace0 \uc788\uc73c\uba70, \uc774\ub294 \uc7a5\uae30\uc801\uc73c\ub85c \uc2dc\uc7a5 \uc131\uc7a5\uc5d0 \uc81c\uc57d\uc744 \uac00\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n*   1\uc138\ub300 PARP \uc5b5\uc81c\uc81c\uc758 2028-2030\ub144 \ud2b9\ud5c8 \ub9cc\ub8cc: 1\uc138\ub300 PARP \uc5b5\uc81c\uc81c\ub294 2028~2030\ub144\uc5d0 \ud2b9\ud5c8 \ub9cc\ub8cc\ub97c \uc55e\ub450\uace0 \uc788\uc5b4, \uac00\uaca9 \ubbfc\uac10\ub3c4\uac00 \ub192\uc740 \uc2dc\uc7a5\uc5d0\uc11c \ubc14\uc774\uc624\uc2dc\ubc00\ub7ec \uacbd\uc7c1\uc73c\ub85c \uc778\ud55c \uac00\uaca9 \uc555\ubc15\uc774 \uc608\uc0c1\ub429\ub2c8\ub2e4.<\/p>\n<p># 4. \uc138\uadf8\uba3c\ud2b8 \ubd84\uc11d<\/p>\n<p>4.1. \uc57d\ubb3c \uc720\ud615\ubcc4: ATM \ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc81c\uc758 \uc131\uc7a5 \ubaa8\uba58\ud140<\/p>\n<p>PARP \uc5b5\uc81c\uc81c\ub294 2025\ub144 DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5 \uc810\uc720\uc728\uc758 49.02%\ub97c \ucc28\uc9c0\ud558\uba70 \ub09c\uc18c\uc554, \uc720\ubc29\uc554, \uc804\ub9bd\uc120\uc554 \uc804\ubc18\uc5d0 \uac78\uccd0 \ud655\uace0\ud55c \uc0c1\uc5c5\uc801 \uc785\uc9c0\ub97c \uc720\uc9c0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uacc4\uc5f4\uc758 \uc2dc\uc7a5 \uaddc\ubaa8\ub294 \uafb8\uc900\ud788 \ud655\ub300\ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uc9c0\ub9cc, \uacbd\uc7c1 \uac15\ub3c4\ub294 \uc2ec\ud654\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. ATM \ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc81c\ub294 \ub77c\ub974\ud14c\uc11c\ud301(lartesertib) \ub4f1 \ud30c\uc774\ud504\ub77c\uc778 \uc57d\ubb3c\ub4e4\uc774 \ud6c4\uae30 \uc784\uc0c1 \ub2e8\uacc4\uc5d0 \uc9c4\uc785\ud558\uba74\uc11c 18.92%\uc758 CAGR\ub85c \uac00\uc7a5 \ube60\ub974\uac8c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc804\ub9dd\ub429\ub2c8\ub2e4. \uc774\ub4e4\uc740 ATM \uc190\uc2e4\uc744 \uac00\uc9c4 \uc885\uc591(\uc804\ub9bd\uc120\uc554, \ucdcc\uc7a5\uc554, \uc704\uc554\uc758 5\u20138%)\uc5d0 \ub300\ud55c \ud65c\uc131\uc73c\ub85c \uc8fc\ubaa9\ubc1b\uace0 \uc788\uc73c\uba70, PARP \uce58\ub8cc\uc5d0 \ub0b4\uc131\uc744 \ubcf4\uc600\ub358 \uc885\uc591\uc5d0\uc11c\ub3c4 \uac1d\uad00\uc801\uc778 \ubc18\uc751\uc744 \ubcf4\uc5ec \ub0b4\uc131 \uad00\ub9ac \uc635\uc158\uc73c\ub85c \uc790\ub9ac\ub9e4\uae40\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uacbd\uad6c\uc6a9 \uc81c\ud615\uc740 \uc678\ub798 \uc885\uc591\ud559 \ud2b8\ub80c\ub4dc\uc640 \uc77c\uce58\ud558\uc5ec \uc804\ubb38 \uc57d\uad6d\uc744 \ud1b5\ud55c \ucc44\ub110 \uce68\ud22c\ub97c \uac15\ud654\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. 1\uc138\ub300 PARP \uc81c\uc81c\uc758 \ud2b9\ud5c8 \ub9cc\ub8cc\uac00 \uc608\uc0c1\ub418\ub294 2030\ub144\uacbd\uc5d0\ub294 ATM \uc5b5\uc81c\uc81c\uac00 PARP \uc81c\uc81c\uc758 \uc120\ub450\ub97c \uc7a0\uc2dd\ud560 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>4.2. \uc801\uc751\uc99d\ubcc4: \uc804\ub9bd\uc120\uc554\uc758 \uc131\uc7a5 \uc8fc\ub3c4<\/p>\n<p>\ub09c\uc18c\uc554\uc740 PARP \uc720\uc9c0 \uc694\ubc95\uc758 \ud655\ub9bd\uacfc HRD\uc758 \ub192\uc740 \uc720\ubcd1\ub960\ub85c \uc778\ud574 2025\ub144 \ub9e4\ucd9c\uc758 38.72%\ub97c \ucc28\uc9c0\ud588\uc2b5\ub2c8\ub2e4. \uc774 \uc801\uc751\uc99d\uc758 \uc2dc\uc7a5 \uaddc\ubaa8\ub294 \uacac\uace0\ud558\uc9c0\ub9cc, \uc120\uc9c4 \uc2dc\uc7a5\uc5d0\uc11c\uc758 \uce68\ud22c\uc728\uc774 \ud3ec\ud654 \uc0c1\ud0dc\uc5d0 \uac00\uae4c\uc6cc\uc9c0\uba74\uc11c \uc131\uc7a5\uc740 \ub454\ud654\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ubc18\uba74, \uc804\ub9bd\uc120\uc554\uc740 \uc62c\ub77c\ud30c\ub9bd-\uc544\ube44\ub77c\ud14c\ub860 \ubcd1\uc6a9 \uc694\ubc95\uc774 \uc911\uc559 \uc0dd\uc874 \uae30\uac04\uc744 42.1\uac1c\uc6d4\ub85c \uc5f0\uc7a5\ud558\ub294 \ub4f1 \uc124\ub4dd\ub825 \uc788\ub294 \uc804\uccb4 \uc0dd\uc874\uc728(OS) \uac1c\uc120\uc744 \ubcf4\uc5ec 17.86%\uc758 CAGR\ub85c \uc2dc\uc7a5\uc744 \uc8fc\ub3c4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc804\uc774\uc131 \uac70\uc138 \uc800\ud56d\uc131 \uc804\ub9bd\uc120\uc554 \uc678\uc5d0\ub3c4, \uc2a4\ud3f0\uc11c\ub4e4\uc740 \ud638\ub974\ubaac \uac10\uc218\uc131 \ubc0f \uad6d\uc18c \uc804\ub9bd\uc120\uc554 \ud658\uacbd\uc5d0\uc11c \ubcd1\uc6a9 \uc694\ubc95\uc744 \uc2dc\ud5d8\ud558\uace0 \uc788\uc5b4, \uc801\uaca9 \ud658\uc790\uad70\uc774 4\ubc30 \uc99d\uac00\ud560 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. APODDC \uac00\uc774\ub4dc\ub77c\uc778\uc5d0 \ub530\ub978 NGS \ucc44\ud0dd \uc99d\uac00\ub294 \uc544\uc2dc\uc544 \ud0dc\ud3c9\uc591 \uc9c0\uc5ed \uc804\ubc18\uc758 \uc9c4\ub2e8\uc728\uc744 \ub354\uc6b1 \ub192\uc5ec \uc218\uc694 \uc131\uc7a5\uc744 \uac15\ud654\ud560 \uac83\uc785\ub2c8\ub2e4. \ub3d9\uc2dc\uc5d0 \ucdcc\uc7a5\uc554\uacfc \ub300\uc7a5\uc554\uc740 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc758 \uac1c\ubc1c\uacfc \uc9c4\ub2e8 \uae30\uc220\uc758 \ubc1c\uc804\uc73c\ub85c \uc778\ud574 \uc0c1\ub2f9\ud55c \uc131\uc7a5 \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc774\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ubcf8 \ubcf4\uace0\uc11c\ub294 DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5\uc5d0 \ub300\ud55c \ud3ec\uad04\uc801\uc778 \ubd84\uc11d\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774 \uc2dc\uc7a5\uc740 \uc554 \ubc0f \ud2b9\uc815 \uc720\uc804 \uc9c8\ud658\uc5d0\uc11c \ud569\uc131 \uce58\uc0ac(synthetic lethality)\ub97c \ud65c\uc6a9\ud558\uae30 \uc704\ud574 PARP, ATM, ATR, DNA-PK \ub4f1 \uc138\ud3ec DNA \uc190\uc0c1 \ubc18\uc751 \ud6a8\uc18c\ub97c \uc5b5\uc81c\ud558\uac70\ub098 \uc870\uc808\ud558\ub294 \ucc98\ubc29 \uce58\ub8cc\uc81c\uc758 \uc804 \uc138\uacc4 \ud310\ub9e4 \uac00\uce58\ub97c \uc758\ubbf8\ud569\ub2c8\ub2e4. Mordor Intelligence\uc5d0 \ub530\ub974\uba74, 2025\ub144 \uc2dc\uc7a5 \uae30\uc900 \uac00\uce58\ub294 89\uc5b5 3\ucc9c\ub9cc \ub2ec\ub7ec\ub85c \ud3c9\uac00\ub418\uba70, \uc720\uc804\uc790 \ud3b8\uc9d1 \ub3c4\uad6c, \uc77c\ubc18\uc758\uc57d\ud488 \uac74\uac15\uae30\ub2a5\uc2dd\ud488, \uc81c\uc870 \uc11c\ube44\uc2a4 \uc218\uc775\uc740 \ubcf8 \uc5f0\uad6c \ubc94\uc704\uc5d0\uc11c \uc81c\uc678\ub429\ub2c8\ub2e4.<\/p>\n<p>\uc2dc\uc7a5 \uc131\uc7a5\uc744 \uacac\uc778\ud558\ub294 \uc8fc\uc694 \uc694\uc778\uc73c\ub85c\ub294 HR \uacb0\ud54d \uace0\ud615\uc554 \ubc1c\ubcd1\ub960 \uc99d\uac00, PARP \uc5b5\uc81c\uc81c\uc758 \ucd08\uae30 \uce58\ub8cc \ubc0f \uc720\uc9c0 \uc694\ubc95\uc73c\ub85c\uc758 \uc801\uc751\uc99d \ud655\ub300, \ud569\uc131 \uce58\uc0ac \ubcd1\uc6a9 \uc694\ubc95 \ucc44\ud0dd, \uacbd\uad6c\uc6a9 \ud56d\uc554\uc81c\ub85c\uc758 \uc804\ud658, \uc2e0\uc18d\ud55c \uaddc\uc81c \uc2b9\uc778, \uc815\ubc00 \uc885\uc591\ud559 \uc774\ub2c8\uc154\ud2f0\ube0c\ub97c \ud1b5\ud55c \ub3d9\ubc18 \uc9c4\ub2e8(Companion-Dx) \ud65c\uc6a9 \uc99d\uac00 \ub4f1\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ubc18\uba74, HRD\/BRCA \uac80\uc0ac\uc758 \ub192\uc740 \ube44\uc6a9, \uace8\uc218\uc5b5\uc81c \ubc0f MDS\/AML\uacfc \uac19\uc740 \uc548\uc804\uc131 \ubb38\uc81c\ub85c \uc778\ud55c \uce58\ub8cc \uae30\uac04 \uc81c\ud55c, \ud45c\uc900 \ud654\ud559\uc694\ubc95 \ub300\ube44 \uc804\uccb4 \uc0dd\uc874\uc728(Overall-Survival) \uc774\uc810\uc5d0 \ub300\ud55c \uc9c0\ubd88\uc790\uc758 \uc2ec\uc0ac \uac15\ud654, \uadf8\ub9ac\uace0 1\uc138\ub300 PARP \uc5b5\uc81c\uc81c\uc758 \ud2b9\ud5c8 \ub9cc\ub8cc(2028-2030\ub144)\ub294 \uc2dc\uc7a5 \uc131\uc7a5\uc744 \uc800\ud574\ud558\ub294 \uc8fc\uc694 \uc694\uc778\uc73c\ub85c \uc791\uc6a9\ud569\ub2c8\ub2e4.<\/p>\n<p>DNA \ubcf5\uad6c \uc57d\ubb3c \uc2dc\uc7a5\uc740 PARP \uc5b5\uc81c\uc81c\uc758 \uc784\uc0c1\uc801 \uc720\ud6a8\uc131 \uc785\uc99d\uacfc HRD \uac80\uc0ac \ud655\ub300, ATM, ATR, DNA-PK \uc5b5\uc81c\uc81c \ud30c\uc774\ud504\ub77c\uc778\uc758 \uc9c4\uc804\uc5d0 \ud798\uc785\uc5b4 12.94%\uc758 \uc5f0\ud3c9\uade0 \uc131\uc7a5\ub960(CAGR)\ub85c \ube60\ub974\uac8c \uc131\uc7a5\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud2b9\ud788, \uc804\ub9bd\uc120\uc554 \ubd84\uc57c\ub294 17.86%\uc758 CAGR\ub85c \uac00\uc7a5 \ud070 \uc808\ub300 \uc218\uc775 \uc99d\uac00\ub97c \ubcf4\uc77c \uac83\uc73c\ub85c \uc804\ub9dd\ub418\uba70, \uacbd\uad6c \uc81c\ud615\uc73c\ub85c\uc758 \uc804\ud658\uc5d0 \ub530\ub77c \uc804\ubb38 \ubc0f \uc18c\ub9e4 \uc57d\uad6d \ucc44\ub110\uc740 15.12%\uc758 CAGR\ub85c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4. \uc2dc\uc7a5\uc740 \uc57d\ubb3c \uc720\ud615, \uc801\uc751\uc99d, \uce58\ub8cc \ub77c\uc778, \uc720\ud1b5 \ucc44\ub110, \uadf8\ub9ac\uace0 \uc9c0\uc5ed\ubcc4\ub85c \uc138\ubd84\ud654\ub418\uc5b4 \ubd84\uc11d\ub429\ub2c8\ub2e4.<\/p>\n<p>\uacbd\uc7c1 \ud658\uacbd \ubd84\uc11d\uc740 \uc2dc\uc7a5 \uc9d1\uc911\ub3c4, \ubca4\uce58\ub9c8\ud0b9, \uc2dc\uc7a5 \uc810\uc720\uc728 \ubd84\uc11d\uc744 \ud3ec\ud568\ud558\uba70, AbbVie, AstraZeneca, GlaxoSmithKline, Johnson &#038; Johnson, Merck KGaA, Novartis, Pfizer, Zai Lab \ub4f1 \uc8fc\uc694 \uae30\uc5c5\ub4e4\uc758 \ud504\ub85c\ud544\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ud5a5\ud6c4 \uc2dc\uc7a5 \uae30\ud68c\ub85c\ub294 \ubbf8\ucda9\uc871 \uc218\uc694 \ud3c9\uac00\uc640 \ud568\uaed8, 1\uc138\ub300 PARP \uc5b5\uc81c\uc81c \ud2b9\ud5c8 \ub9cc\ub8cc \uc774\ud6c4 \uace0\uc120\ud0dd\uc131 PARP1 \uc5b5\uc81c\uc81c, WRN \ud5ec\ub9ac\uce74\uc81c \ucc28\ub2e8\uc81c, DNA \uc911\ud569\ud6a8\uc18c \uc138\ud0c0 \uc5b5\uc81c\uc81c, DDR \uae30\ubc18 \ud56d\uccb4-\uc57d\ubb3c \uc811\ud569\uccb4(ADC) \ub4f1 \uc0c8\ub85c\uc6b4 \uae30\uc804\uc758 \uc57d\ubb3c\ub4e4\uc774 \uce58\ub8cc \uc635\uc158\uc744 \ub2e4\uc591\ud654\ud558\uace0 \ub0b4\uc131\uc744 \uc644\ud654\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4. \uc2e0\ud765 \uc2dc\uc7a5\uc5d0\uc11c\ub294 HRD \ubc0f BRCA \uac80\uc0ac\uc758 \ub192\uc740 \ube44\uc6a9\uacfc \uc81c\ud55c\uc801\uc778 \ubcf4\ud5d8 \uc801\uc6a9\uc774 \ud658\uc790 \uc811\uadfc\uc131\uc744 \uc81c\uc57d\ud558\ub294 \uc8fc\uc694 \uc7a5\uc560\ubb3c\ub85c \ub0a8\uc544\uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ubcf8 \ubcf4\uace0\uc11c\uc758 \uc5f0\uad6c \ubc29\ubc95\ub860\uc740 \uc2ec\uce35\uc801\uc778 1\ucc28(\uc885\uc591 \uc804\ubb38\uc758, \uc57d\uc0ac \ub4f1 \uc778\ud130\ubdf0) \ubc0f 2\ucc28(\uc784\uc0c1 \uc800\ub110, \uc554 \ub4f1\ub85d \ub370\uc774\ud130, \uaddc\uc81c \uae30\uad00 \uc790\ub8cc, \uae30\uc5c5 \ubcf4\uace0\uc11c \ub4f1) \uc870\uc0ac\ub97c \uae30\ubc18\uc73c\ub85c \ud569\ub2c8\ub2e4. \uc2dc\uc7a5 \uaddc\ubaa8 \uc0b0\uc815 \ubc0f \uc608\uce21\uc740 \ud558\ud5a5\uc2dd \ubc0f \uc0c1\ud5a5\uc2dd \ubaa8\ub378\uc744 \uad50\ucc28 \uac80\uc99d\ud558\uc5ec \uc774\ub8e8\uc5b4\uc84c\uc73c\uba70, \ub370\uc774\ud130\ub294 \ub3c5\ub9bd\uc801\uc778 \uc218\uc785 \ub370\uc774\ud130 \ubc0f \ubd84\uae30\ubcc4 \uc2e4\uc801\uacfc \ube44\uad50\ud558\uc5ec \uac80\uc99d\ub418\uace0 \uc8fc\uc694 \uc2dc\uc7a5 \ubcc0\ub3d9 \uc2dc \uc911\uac04 \uc5c5\ub370\uc774\ud2b8\uac00 \uc9c4\ud589\ub429\ub2c8\ub2e4.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-41538","post","type-post","status-publish","format-standard","hentry","category-market-reports"],"_links":{"self":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/posts\/41538"}],"collection":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/comments?post=41538"}],"version-history":[{"count":0,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/posts\/41538\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/media?parent=41538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/categories?post=41538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.globalresearch.co.kr\/insight\/wp-json\/wp\/v2\/tags?post=41538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}